{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:48:23Z","timestamp":1786978103228,"version":"build-2736575974"},"reference-count":105,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T00:00:00Z","timestamp":1537574400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17K10825"],"award-info":[{"award-number":["17K10825"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["17K16640"],"award-info":[{"award-number":["17K16640"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2020,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Subarachnoid hemorrhage (SAH) by a rupture of cerebral aneurysms remains the most devastating cerebrovascular disease. Early brain injury (EBI) is increasingly recognized to be the primary determinant for poor outcomes, and also considered to cause delayed cerebral ischemia (DCI) after SAH. Both clinical and experimental literatures emphasize the impact of global cerebral edema in EBI as negative prognostic and direct pathological factors. The nature of the global cerebral edema is a mixture of cytotoxic and vasogenic edema, both of which may be caused by post\u2010SAH induction of tenascin\u2010C (TNC) that is an inducible, non\u2010structural, secreted and multifunctional matricellular protein. Experimental SAH induces TNC in brain parenchyma in rats and mice. TNC knockout suppressed EBI in terms of brain edema, blood\u2010brain barrier disruption, neuronal apoptosis and neuroinflammation, associated with the inhibition of post\u2010SAH activation of mitogen\u2010activated protein kinases and nuclear factor\u2010kappa B in mice. In a clinical setting, more severe SAH increases more TNC in cerebrospinal fluid and peripheral blood, which could be a surrogate marker of EBI and predict DCI development and outcomes. In addition, cilostazol, a selective inhibitor of phosphodiesterase type III that is a clinically available anti\u2010platelet agent and is known to suppress TNC induction, dose\u2010dependently inhibited delayed cerebral infarction and improved outcomes in a pilot clinical study. Thus, further studies may facilitate application of TNC as biomarkers for non\u2010invasive diagnosis or assessment of EBI and DCI, and lead to development of a molecular target drug against TNC, contributing to the improvement of post\u2010SAH outcomes.<\/jats:p>","DOI":"10.1002\/jnr.24330","type":"journal-article","created":{"date-parts":[[2018,9,22]],"date-time":"2018-09-22T09:15:26Z","timestamp":1537607726000},"page":"42-56","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Tenascin\u2010C in brain injuries and edema after subarachnoid hemorrhage: Findings from basic and clinical studies"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8555-5448","authenticated-orcid":false,"given":"Hidenori","family":"Suzuki","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Mie University Graduate School of Medicine Tsu Japan"},{"name":"Research Center for Matrix Biology Mie University Graduate School of Medicine Tsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masashi","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Mie University Graduate School of Medicine Tsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumihiro","family":"Kawakita","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Mie University Graduate School of Medicine Tsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Mie University Graduate School of Medicine Tsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinari","family":"Nakatsuka","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Mie University Graduate School of Medicine Tsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumi","family":"Nakano","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Mie University Graduate School of Medicine Tsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirofumi","family":"Nishikawa","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Mie University Graduate School of Medicine Tsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Okada","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Mie University Graduate School of Medicine Tsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Kanamaru","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Mie University Graduate School of Medicine Tsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoko","family":"Imanaka\u2010Yoshida","sequence":"additional","affiliation":[{"name":"Research Center for Matrix Biology Mie University Graduate School of Medicine Tsu Japan"},{"name":"Department of Pathology and Matrix Biology Mie University Graduate School of Medicine Tsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshimichi","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Research Center for Matrix Biology Mie University Graduate School of Medicine Tsu Japan"},{"name":"Department of Pathology and Matrix Biology Mie University Graduate School of Medicine Tsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Shiba","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery Mie University Graduate School of Medicine Tsu Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,9,22]]},"reference":[{"key":"e_1_2_18_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyx364"},{"key":"e_1_2_18_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2004.07.156"},{"key":"e_1_2_18_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-016-0485-3"},{"key":"e_1_2_18_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-018-0614-2"},{"key":"e_1_2_18_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000053848.06436.AB"},{"key":"e_1_2_18_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0955-0674(02)00361-7"},{"key":"e_1_2_18_8_1","article-title":"Heroin use is associated with ruptured saccular aneurysms","author":"Can A.","year":"2017","journal-title":"Translational Stroke Research"},{"key":"e_1_2_18_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-017-0557-z"},{"key":"e_1_2_18_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.06.025"},{"key":"e_1_2_18_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000246172.77441.f1"},{"key":"e_1_2_18_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2009.01.012"},{"key":"e_1_2_18_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2004.08.001"},{"key":"e_1_2_18_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1415"},{"key":"e_1_2_18_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000015624.29071.1F"},{"key":"e_1_2_18_16_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1511794112"},{"key":"e_1_2_18_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-018-0641-z"},{"key":"e_1_2_18_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2015.06.004"},{"key":"e_1_2_18_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2016.11.003"},{"key":"e_1_2_18_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2017.07.003"},{"key":"e_1_2_18_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2007.04.001"},{"key":"e_1_2_18_22_1","doi-asserted-by":"publisher","DOI":"10.1227\/01.NEU.0000218821.34014.1B"},{"key":"e_1_2_18_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.04.034"},{"key":"e_1_2_18_24_1","doi-asserted-by":"publisher","DOI":"10.3171\/2015.4.JNS15484"},{"key":"e_1_2_18_25_1","first-page":"131","volume-title":"Neurovascular events after subarachnoid hemorrhage","author":"Fujimoto M.","year":"2017"},{"key":"e_1_2_18_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-017-0466-x"},{"key":"e_1_2_18_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2013.01.007"},{"key":"e_1_2_18_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtcvs.2003.11.015"},{"key":"e_1_2_18_29_1","doi-asserted-by":"publisher","DOI":"10.4161\/19336918.2014.987587"},{"key":"e_1_2_18_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvr183"},{"key":"e_1_2_18_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072-009-0192-x"},{"key":"e_1_2_18_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-016-0511-5"},{"issue":"10","key":"e_1_2_18_33_1","first-page":"2021","article-title":"Tenascin\u2010C concentration in synovial fluid correlates with radiographic progression of knee osteoarthritis","volume":"31","author":"Hasegawa M.","year":"2004","journal-title":"Journal of Rheumatology"},{"key":"e_1_2_18_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-016-0354-7"},{"key":"e_1_2_18_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-015-0809-9"},{"key":"e_1_2_18_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1131"},{"key":"e_1_2_18_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22614"},{"key":"e_1_2_18_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2016.12.012"},{"key":"e_1_2_18_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-016-0513-3"},{"key":"e_1_2_18_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-016-0178-7"},{"key":"e_1_2_18_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-015-9386-9"},{"key":"e_1_2_18_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1006-z"},{"key":"e_1_2_18_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.016629"},{"key":"e_1_2_18_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-66679-2_20"},{"key":"e_1_2_18_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/crj.12428"},{"key":"e_1_2_18_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30668-7"},{"key":"e_1_2_18_47_1","first-page":"353","article-title":"Review and recommendations on management of refractory raised intracranial pressure in aneurysmal subarachnoid hemorrhage","volume":"9","author":"Mak C. H.","year":"2013","journal-title":"Vascular Health and Risk Management"},{"key":"e_1_2_18_48_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.190546"},{"key":"e_1_2_18_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-011-0783-6"},{"key":"e_1_2_18_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12079-009-0075-1"},{"key":"e_1_2_18_51_1","first-page":"151","volume-title":"Neurovascular events after subarachnoid hemorrhage","author":"Nakano F.","year":"2017"},{"key":"e_1_2_18_52_1","article-title":"Link between receptors that engage in developing vasospasm after subarachnoid hemorrhage in mice","author":"Nakano F.","journal-title":"Acta Neurochirurgica. Supplementum"},{"key":"e_1_2_18_53_1","doi-asserted-by":"publisher","DOI":"10.3171\/2016.5.JNS152907"},{"key":"e_1_2_18_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-0893-3"},{"key":"e_1_2_18_55_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-017-0564-0"},{"key":"e_1_2_18_56_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.221150"},{"key":"e_1_2_18_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci8020030"},{"key":"e_1_2_18_58_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0b013e318033dfd4"},{"issue":"2","key":"e_1_2_18_59_1","first-page":"782","article-title":"Tenascin\u2010C expression is associated with poor prognosis in hepatocellular carcinoma (HCC) patients and the inflammatory cytokine TNF\u2010\u03b1\u2010induced TNC expression promotes migration in HCC cells","volume":"5","author":"Nong Y.","year":"2015","journal-title":"American Journal of Cancer Research"},{"key":"e_1_2_18_60_1","doi-asserted-by":"publisher","DOI":"10.1159\/000083093"},{"key":"e_1_2_18_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1145-2"},{"key":"e_1_2_18_62_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.200795"},{"key":"e_1_2_18_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-016-0507-1"},{"key":"e_1_2_18_64_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnint.2017.00030"},{"key":"e_1_2_18_65_1","doi-asserted-by":"publisher","DOI":"10.1385\/NCC:2:2:110"},{"key":"e_1_2_18_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-010-9432-4"},{"key":"e_1_2_18_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-017-0471-y"},{"key":"e_1_2_18_68_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.110.206375"},{"key":"e_1_2_18_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2012.02.003"},{"key":"e_1_2_18_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-017-0540-8"},{"key":"e_1_2_18_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-014-0333-2"},{"key":"e_1_2_18_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2012.01.005"},{"key":"e_1_2_18_73_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.020660"},{"key":"e_1_2_18_74_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-014-0380-8"},{"key":"e_1_2_18_75_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3181c027ae"},{"key":"e_1_2_18_76_1","article-title":"Toll\u2010like receptor 4 and tenascin\u2010C signaling in cerebral vasospasm and brain injuries after subarachnoid hemorrhage","author":"Suzuki H.","journal-title":"Acta Neurochirurgica. Supplementum"},{"key":"e_1_2_18_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-18497-5_27"},{"key":"e_1_2_18_78_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22102"},{"key":"e_1_2_18_79_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.586537"},{"key":"e_1_2_18_80_1","doi-asserted-by":"publisher","DOI":"10.1097\/ANA.0b013e31822aa1f2"},{"key":"e_1_2_18_81_1","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/978-3-319-04981-6_20","article-title":"Tenascin\u2010C is a possible mediator between initial brain injury and vasospasm\u2010related and \u2010unrelated delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage","volume":"120","author":"Suzuki H.","year":"2015","journal-title":"Acta Neurochirurgica. Supplementum"},{"key":"e_1_2_18_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-211-75718-5_35"},{"key":"e_1_2_18_83_1","doi-asserted-by":"publisher","DOI":"10.1179\/174313208X355495"},{"key":"e_1_2_18_84_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.177721"},{"key":"e_1_2_18_85_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.505735"},{"key":"e_1_2_18_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-017-0546-2"},{"key":"e_1_2_18_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-018-0650-y"},{"key":"e_1_2_18_88_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.235022"},{"key":"e_1_2_18_89_1","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/978-3-7091-1192-5_39","article-title":"Matricellular protein: A new player in cerebral vasospasm following subarachnoid hemorrhage","volume":"115","author":"Suzuki H.","year":"2013","journal-title":"Acta Neurochirurgica. Supplementum"},{"key":"e_1_2_18_90_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-016-0500-8"},{"key":"e_1_2_18_91_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1478-3231.2005.01229.x"},{"key":"e_1_2_18_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06487"},{"key":"e_1_2_18_93_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2005.103.4.0681"},{"key":"e_1_2_18_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12975-015-0434-6"},{"key":"e_1_2_18_95_1","doi-asserted-by":"publisher","DOI":"10.1387\/ijdb.103243eo"},{"key":"e_1_2_18_96_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.110.589275"},{"key":"e_1_2_18_97_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.ATV.0000134299.89599.53"},{"key":"e_1_2_18_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0735-1097(00)01117-7"},{"key":"e_1_2_18_99_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5825"},{"key":"e_1_2_18_100_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-012-9769-6"},{"key":"e_1_2_18_101_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5181"},{"key":"e_1_2_18_102_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.01138.2004"},{"key":"e_1_2_18_103_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.31.21840"},{"key":"e_1_2_18_104_1","doi-asserted-by":"publisher","DOI":"10.1017\/S1462399408000719"},{"key":"e_1_2_18_105_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.57.10.1212"},{"key":"e_1_2_18_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-010-0684-8"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.24330","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/am-pdf\/10.1002%2Fjnr.24330","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.24330","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T07:00:16Z","timestamp":1694156416000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.24330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,22]]},"references-count":105,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["10.1002\/jnr.24330"],"URL":"https:\/\/doi.org\/10.1002\/jnr.24330","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,22]]},"assertion":[{"value":"2018-06-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-08-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2018-09-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}