{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T11:17:11Z","timestamp":1793186231550,"version":"4.5.0"},"reference-count":64,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T00:00:00Z","timestamp":1543449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000097","name":"National Center for Research Resources","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["P41 EB015909"],"award-info":[{"award-number":["P41 EB015909"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001068","name":"Dana Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001068","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000887","name":"Huntington's Disease Society of America","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000887","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11,775,184"],"award-info":[{"award-number":["11,775,184"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Altered brain iron content in the striatum of premanifest and manifest Huntington\u2019s disease (HD) has been reported. However, its natural history remains unclear. This study aims to investigate altered brain iron content in premanifest and early HD, and the iron deposition rate in these patients through a longitudinal one\u2010year follow\u2010up test, with quantitative magnetic susceptibility as an iron imaging marker. Twenty\u2010four gene mutation carriers divided into three groups (further\u2010from\u2010onset, closer\u2010to\u2010onset and early HD) and 16 age\u2010matched healthy controls were recruited at baseline, and of these, 14 carriers and 7 controls completed the one\u2010year follow\u2010up. Quantitative magnetic susceptibility and effective transverse relaxation rate (\n                    <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jnr24358-math-0001.png\" xlink:title=\"urn:x-wiley:03604012:media:jnr24358:jnr24358-math-0001\"\/>\n                    ) were measured at 7.0 Tesla and correlated with atrophy and available clinical and cognitive measurements. Higher susceptibility values indicating higher iron content in the striatum and globus pallidus were only observed in closer\u2010to\u2010onset (\n                    <jats:italic>N<\/jats:italic>\n                    \u00a0=\u00a06,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05 in caudate and\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.01 in putamen) and early HD (\n                    <jats:italic>N<\/jats:italic>\n                    \u00a0=\u00a09,\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.05 in caudate and globus pallidus and\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u00a00.01 in putamen). Similar results were found by\n                    <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jnr24358-math-0002.png\" xlink:title=\"urn:x-wiley:03604012:media:jnr24358:jnr24358-math-0002\"\/>\n                    measurement. Such increases directly correlated with HD CAG\u2013age product score and brain atrophy, but not with motor or cognitive scores. More importantly, a significantly higher iron deposition rate (11.9%\/years in caudate and 6.1%\/years in globus pallidus) was firstly observed in closer\u2010to\u2010onset premanifest HD and early HD as compared to the controls. These results suggest that monitoring brain iron may provide further insights into the pathophysiology of HD disease progression, and may provide a biomarker for clinical trials.\n                  <\/jats:p>","DOI":"10.1002\/jnr.24358","type":"journal-article","created":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T11:18:34Z","timestamp":1543490314000},"page":"467-479","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Altered brain iron content and deposition rate in Huntington\u2019s disease as indicated by quantitative susceptibility MRI"],"prefix":"10.1002","volume":"97","author":[{"given":"Lin","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Xiamen University Xiamen China"},{"name":"F.M. Kirby Research Center for Functional Brain Imaging Kennedy Krieger Institute Baltimore Maryland"},{"name":"Department of Radiology and Radiological Sciences Johns Hopkins University Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Hua","sequence":"additional","affiliation":[{"name":"F.M. Kirby Research Center for Functional Brain Imaging Kennedy Krieger Institute Baltimore Maryland"},{"name":"Department of Radiology and Radiological Sciences Johns Hopkins University Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Ross","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, Division of Neurobiology Johns Hopkins University Baltimore Maryland"},{"name":"Departments of Neurology, Neuroscience and Pharmacology Johns Hopkins University Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhui","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Electronic Science, Fujian Provincial Key Laboratory of Plasma and Magnetic Resonance Xiamen University Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter C.M.","family":"van Zijl","sequence":"additional","affiliation":[{"name":"F.M. Kirby Research Center for Functional Brain Imaging Kennedy Krieger Institute Baltimore Maryland"},{"name":"Department of Radiology and Radiological Sciences Johns Hopkins University Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4350-3375","authenticated-orcid":false,"given":"Xu","family":"Li","sequence":"additional","affiliation":[{"name":"F.M. Kirby Research Center for Functional Brain Imaging Kennedy Krieger Institute Baltimore Maryland"},{"name":"Department of Radiology and Radiological Sciences Johns Hopkins University Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/currents.RRN1235"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1996.00550120105023"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2011.07.030"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000132965.14653.D1"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.208264"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx137"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2016.2544958"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2015.02.021"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-007-9352-7"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2011.08.077"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-15-36"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1109\/TIP.2011.2158229"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2016.12.033"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.09.055"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/nbm.3569"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1006846"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1416"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-310183"},{"issue":"3","key":"e_1_2_12_20_1","first-page":"373","article-title":"Magnetic resonance imaging of brain iron","volume":"7","author":"Drayer B.","year":"1986","journal-title":"American Journal of Neuroradiology"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26417"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2012.03.056"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200101)49:1<29::AID-ANA7>3.0.CO;2-B"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mri.2004.10.001"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/hbm.22928"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/9.19.2789"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1371\/currents.RRN1173"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-008-0050-4"},{"issue":"3","key":"e_1_2_12_29_1","first-page":"1593","article-title":"Quantitative susceptibility mapping (QSM) as a means to measure brain iron?","volume":"62","author":"Langkammer C.","year":"2012","journal-title":"A Post Mortem Validation Study. 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