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Protein Kinase C epsilon (PKC\u03b5) is a member of the novel PKC subfamily and plays a vital role in ischemic preconditioning. Pharmacological activation of PKC\u03b5 before cerebral ischemia confers neuroprotection. The role of endogenous PKC\u03b5 after cerebral ischemia remains elusive. Here we used male PKC\u03b5\u2010null mice to assess the effects of PKC\u03b5 deficiency on neurodegeneration after transient global cerebral ischemia (tGCI). We found that the cerebral vasculature, blood flow, and the expression of other PKC isozymes were not altered in the PKC\u03b5\u2010null mice. Spatial learning and memory was impaired after tGCI, but the impairment was attenuated in male PKC\u03b5\u2010null mice as compared to male wild\u2010type controls. A significant reduction in Fluoro\u2010Jade C labeling and mitochondrial release of cytochrome C in the hippocampus was found in male PKC\u03b5\u2010null mice after tGCI. Male PKC\u03b5\u2010null mice expressed increased levels of PKC\u03b4 in the mitochondria, which may prevent the translocation of PKC\u03b4 from the cytosol to the mitochondria after tGCI. Our results demonstrate the neuroprotective effects of PKC\u03b5 deficiency on neurodegeneration after tGCI, and suggest that reduced mitochondrial translocation of PKC\u03b4 may contribute to the neuroprotective action in male PKC\u03b5\u2010null mice.<\/jats:p>","DOI":"10.1002\/jnr.24362","type":"journal-article","created":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T12:43:04Z","timestamp":1543495384000},"page":"444-455","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Genetic inhibition of PKC\u03b5 attenuates neurodegeneration after global cerebral ischemia in male mice"],"prefix":"10.1002","volume":"97","author":[{"given":"Varun","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Biological Sciences, School of Biomedical Sciences Kent State University Kent 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