{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:25:12Z","timestamp":1785324312288,"version":"3.55.0"},"reference-count":56,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T00:00:00Z","timestamp":1548288000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009123","name":"Norges Teknisk-Naturvitenskapelige Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009123","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2019,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Aims of this study were to investigate white matter (WM) and thalamus microstructure 72\u00a0hr and 3 months after mild traumatic brain injury (TBI) with diffusion kurtosis imaging (DKI) and diffusion tensor imaging (DTI), and to relate DKI and DTI findings to postconcussional syndrome (PCS). Twenty\u2010five patients (72\u00a0hr = 24; 3 months = 23) and 22 healthy controls were recruited, and DKI and DTI data were analyzed with Tract\u2010Based Spatial Statistics (TBSS) and a region\u2010of\u2010interest (ROI) approach. Patients were categorized into PCS or non\u2010PCS 3 months after injury according to the ICD\u201010 research criteria for PCS. In TBSS analysis, significant differences between patients and controls were seen in WM, both in the acute stage and 3 months after injury. Fractional anisotropy (FA) reductions were more widespread than kurtosis fractional anisotropy (KFA) reductions in the acute stage, while KFA reductions were more widespread than the FA reductions at 3 months, indicating the complementary roles of DKI and DTI. When comparing patients with PCS (<jats:italic>n<\/jats:italic> = 9), without PCS (<jats:italic>n<\/jats:italic> = 16), and healthy controls, in the ROI analyses, no differences were found in the acute DKI and DTI metrics. However, near\u2010significant differences were observed for several DKI metrics obtained in WM and thalamus concurrently with symptom assessment (3 months after injury). Our findings indicate a combined utility of DKI and DTI in detecting WM microstructural alterations after mild TBI. Moreover, PCS may be associated with evolving alterations in brain microstructure, and DKI may be a promising tool to detect such changes.<\/jats:p>","DOI":"10.1002\/jnr.24383","type":"journal-article","created":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T20:43:07Z","timestamp":1548362587000},"page":"568-581","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["Diffusion kurtosis imaging in mild traumatic brain injury and postconcussional syndrome"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3435-9156","authenticated-orcid":false,"given":"Rune Hatlestad","family":"Karlsen","sequence":"first","affiliation":[{"name":"Department of Neuromedicine and Movement Science Norwegian University of Science and Technology (NTNU) Trondheim 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