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In this study, we investigated the timing behavior of the 5xFAD mouse model of AD in the peak interval (PI) procedure. Nine\u2010month\u2010old female mice were trained with sucrose solution reinforcement for their first response after a fixed\u2010interval (FI) and tested in the inter\u2010mixed non\u2010reinforced PI trials that lasted longer than FI. Timing performance indices were estimated from steady\u2010state timed anticipatory nose\u2010poking responses in the PI trials. We found that the time of maximal reward expectancy (peak time) of the 5xFAD mice was significantly earlier than that of the wild\u2010type (WT) controls with no differences in other indices of timing performance. These behavioral differences corroborate the findings of previous studies on the disruption of temporal associative memory abilities of 5xFAD mice and can be accounted for by the scalar timing theory based on altered long\u2010term memory consolidation of temporal information in the 5xFAD mice. This is the first study to directly show an interval timing phenotype in a genetic mouse model of AD.<\/jats:p>","DOI":"10.1002\/jnr.24418","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T02:27:46Z","timestamp":1555036066000},"page":"817-827","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Interval timing is disrupted in female 5xFAD mice: An indication of altered memory processes"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3103-2446","authenticated-orcid":false,"given":"Ezgi","family":"G\u00fcr","sequence":"first","affiliation":[{"name":"Timing and Decision Making Laboratory, Psychology Department Ko\u00e7 University Istanbul Turkey"},{"name":"Research Center for Translational Medicine Ko\u00e7 University Istanbul 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