{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T21:32:05Z","timestamp":1773869525288,"version":"3.50.1"},"reference-count":67,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T00:00:00Z","timestamp":1558483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:sec><jats:label\/><jats:p>Parkinson's disease (PD) is a disabling and highly costly neurodegenerative condition with worldwide prevalence. Despite advances in treatments that slow progression and minimize locomotor impairments, its clinical management is still a challenge. Previous preclinical studies, using mesenchymal stem cell (MSC) transplantation and isolated physical exercise (EX), reported beneficial results for treatment of PD. Therefore, this experimental randomized study aimed to elucidate the therapeutic potential of combined therapy using adipose\u2010derived human MSCs (ADSCs) grafted into the striatum in conjunction with aerobic treadmill training, specifically in terms of locomotor performance in a unilateral PD rat model induced by 6\u2010hydroxydopamine (6\u2010OHDA). Forty\u2010one male Wistar rats were categorized into five groups in accordance with the type of treatment to which they were subjected (Sham, 6\u2010OHDA\u00a0\u2212\u00a0injury, 6\u2010OHDA\u00a0+\u00a0exercise, 6\u2010OHDA\u00a0+\u00a0cells, and 6\u2010OHDA\u00a0+\u00a0combined). Subsequently, dopaminergic depletion was assessed by the methylphenidate challenge and the specified therapeutic intervention was conducted in each group. The foot fault task was performed at the end of the experiment to serve as an assessment of motor skills. The results showed that despite disturbances in motor balance and coordination, locomotor dysfunction was ameliorated in all treatment categories in comparison to the injury group (sign test, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001, effect size: 0.71). The exercise alone and combined groups were the categories that exhibited the best recovery in terms of movement performance (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001). Overall, this study confirms that exercise is a powerful option to improve motor function and a promising adjuvant intervention for stem cell transplantation in the treatment of PD motor symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Open Practices<\/jats:title><jats:p>\n<jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"graphic\/jnr24442-gra-0001.png\" xlink:title=\"image\"\/>\n<\/jats:p><jats:p>This article has been awarded Open Data. All materials and data are publicly accessible at <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/figshare.com\/s\/18a543c101a17a1d5560\">https:\/\/figshare.com\/s\/18a543c101a17a1d5560<\/jats:ext-link>. Learn more about the Open Practices badges from the Center for Open Science: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/osf.io\/tvyxz\/wiki\">https:\/\/osf.io\/tvyxz\/wiki<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1002\/jnr.24442","type":"journal-article","created":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T14:33:47Z","timestamp":1558622027000},"page":"1095-1109","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Physical exercise and human adipose\u2010derived mesenchymal stem cells ameliorate motor disturbances in a male rat model of Parkinson's disease"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7281-7840","authenticated-orcid":false,"given":"Jaison D.","family":"Cucari\u00e1n","sequence":"first","affiliation":[{"name":"Graduate Course in Rehabilitation Sciences, Federal University of Health Sciences of Porto Alegre Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny P.","family":"Berr\u00edo","sequence":"additional","affiliation":[{"name":"Graduate Course in Rehabilitation Sciences, Federal University of Health Sciences of Porto Alegre Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristiano","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Cell Biology Research Laboratory Federal University of Health Sciences of Porto Alegre Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Zancan","sequence":"additional","affiliation":[{"name":"Graduate Course in Neuroscience Federal University of Rio Grande do Sul Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcia R.","family":"Wink","sequence":"additional","affiliation":[{"name":"Cell Biology Research Laboratory Federal University of Health Sciences of Porto Alegre Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alcyr","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Graduate Course in Rehabilitation Sciences, Federal University of Health Sciences of Porto Alegre Porto Alegre Brazil"},{"name":"Graduate Course in Psychology and Health Federal University of Health Sciences of Porto Alegre Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.4252\/wjsc.v8.i3.106"},{"key":"e_1_2_12_3_1","article-title":"Neurodegenerative diseases: Exercising toward neurogenesis and neuroregeneration","volume":"2","author":"Ang E.\u2010T.","year":"2010","journal-title":"Frontiers in Aging Neuroscience"},{"issue":"7","key":"e_1_2_12_4_1","first-page":"e0133002","article-title":"Sex differences in clinical features of early","volume":"10","author":"Augustine E. F.","year":"2015","journal-title":"Treated Parkinson's Disease. PLoS One"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jez.b.22646"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/dneu.20401"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(03)00212-7"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12015-014-9551-y"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1037\/pne0000099"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2008.02.003"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2007.02.009"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-8-14"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.12965\/jer.130048"},{"issue":"2","key":"e_1_2_12_14_1","first-page":"798","article-title":"Effects of alpha\u20102 adrenoceptor agonists and antagonists on circling behavior in rats with unilateral 6\u2010hydroxydopamine lesions of the nigrostriatal pathway","volume":"288","author":"Chopin P.","year":"1999","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2007.06.011"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.iac.2009.11.005"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/14653240600855905"},{"key":"e_1_2_12_18_1","first-page":"14","article-title":"Epidemiology of Parkinson's disease","volume":"172","author":"Elbaz A.","year":"2016","journal-title":"Neuroepidemiology"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867325666180313101536"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2005.04.005"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X658746"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-011-0082-9"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40064-015-1400-1"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2014.02.002"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2016.00007"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.5213\/inj.1734856.428"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1089\/rej.2014.1626"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5359-13.2014"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-010-0495-3"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature23664"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2013.10.054"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.2217\/rme.11.2"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/9832839"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2003.056598"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.02932"},{"key":"e_1_2_12_36_1","article-title":"Effects of exercise in combination with autologous bone marrow stem cell transplantation for patients with type 1 diabetes","volume":"1","author":"Mohamed M. T.","year":"2018","journal-title":"Physiotherapy Theory and Practice"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X657242"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40303-015-0010-8"},{"issue":"9","key":"e_1_2_12_39_1","doi-asserted-by":"crossref","first-page":"e5319","DOI":"10.1590\/1414-431x20165319","article-title":"Human dental pulp stem cells transplantation combined with treadmill training in rats after traumatic spinal cord injury","volume":"49","author":"Nicola F. C.","year":"2016","journal-title":"Brazilian Journal of Medical and Biological Research = Revista Brasileira de Pesquisas Medicas e Biologicas"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.6061\/clinics\/2013(06)24"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.2015.1091727"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X640556"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13258-014-0239-0"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2012.05.032"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.3233\/BPL-150021"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0117391"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.269"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1186\/2040-7378-2-13"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.2217\/rme.15.17"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.12965\/jer.1734906.453"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2008.10.030"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.235085"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2016.03.012"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2005.06.017"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.177710"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.459"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2011.06.012"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.2651"},{"issue":"35","key":"e_1_2_12_59_1","first-page":"3353","article-title":"Differentiation of human adipose\u2010derived stem cells into neuron\u2010like cells by Radix Angelicae Sinensis","volume":"8","author":"Wang Q.","year":"2013","journal-title":"Neural Regeneration Research"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2014.08.016"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4382518"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105216"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1634\/stemcells.2007-0494"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2006.07.013"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-012-9850-2"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.13460"},{"key":"e_1_2_12_67_1","first-page":"178","article-title":"Expression pattern of neurotrophins and their receptors during neuronal differentiation of adipose\u2010derived stem cells in simulated microgravity condition","volume":"20","author":"Zarrinpour V.","year":"2017","journal-title":"Iranian Journal of Basic Medical Sciences"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-0270(02)00114-0"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.24442","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.24442","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jnr.24442","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.24442","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,9]],"date-time":"2023-09-09T12:33:19Z","timestamp":1694262799000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.24442"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5,22]]},"references-count":67,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["10.1002\/jnr.24442"],"URL":"https:\/\/doi.org\/10.1002\/jnr.24442","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,5,22]]},"assertion":[{"value":"2018-08-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-04-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-05-22","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}