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Annexin A1\u2010FPR2 signaling has been shown to play a protective role in animal stroke models. This study aimed to assess whether Annexin A1 attenuated neuroinflammation and brain edema after ICH and investigate the underlying mechanisms. Male CD\u20101 mice were subjected to collagenase\u2010induced ICH. Annexin A1 was administered at 0.5\u00a0hr after ICH. Brain water content measurement, short\u2010term and long\u2010term neurobehavioral tests, Western blot and immnunofluorescence were performed. Results showed that Annexin A1 effectively attenuated brain edema, improved short\u2010term neurological function and ameliorated microglia activation after ICH. Annexin A1 also improved memory function at 28\u00a0days after ICH. However, these beneficial effects were abolished with the administration of FPR2 antagonist Boc\u20102. Furthermore, AnxA1\/FPR2 signaling may confer protective effects via inhibiting p38\u2010associated inflammatory cascade. Our study demonstrated that Annexin A1\/FPR2\/p38 signaling pathway played an important role in attenuating neuroinflammation after ICH and that Annexin A1 could be a potential therapeutic strategy for ICH patients.<\/jats:p>","DOI":"10.1002\/jnr.24478","type":"journal-article","created":{"date-parts":[[2019,6,3]],"date-time":"2019-06-03T11:05:48Z","timestamp":1559559948000},"page":"168-178","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Annexin A1 attenuates neuroinflammation through FPR2\/p38\/COX\u20102 pathway after intracerebral hemorrhage in male mice"],"prefix":"10.1002","volume":"98","author":[{"given":"Yan","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Basic Sciences, School of Medicine Loma Linda University Loma Linda California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5967-5999","authenticated-orcid":false,"given":"Jerry","family":"Flores","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, School of Medicine Loma Linda University Loma Linda California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damon","family":"Klebe","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, School of Medicine Loma Linda University Loma Linda California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, School of Medicine Loma Linda University Loma Linda California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8988-3353","authenticated-orcid":false,"given":"Devin W.","family":"MBride","sequence":"additional","affiliation":[{"name":"The Vivian L. 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