{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T22:09:14Z","timestamp":1759615754029,"version":"3.40.5"},"reference-count":58,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2019,6,30]],"date-time":"2019-06-30T00:00:00Z","timestamp":1561852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100006345","name":"Uniwersytet Mikolaja Kopernika w Toruniu","doi-asserted-by":"publisher","award":["1197-B"],"award-info":[{"award-number":["1197-B"]}],"id":[{"id":"10.13039\/501100006345","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2016\/21\/N\/NZ7\/00399"],"award-info":[{"award-number":["2016\/21\/N\/NZ7\/00399"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Anoxia during delivery is a complication that can disturb infant brain development leading to various types of neurological disorders. Our studies have shown that increased body temperature of newborn rats of both sexes intensifies the postanoxic oxidative stress and prevents triggering the endogenous adaptive response such as HIF\u20101\u03b1 activation. Currently, brain\u2010derived neurotrophic factor\u2010BDNF is considered to be a modulator of neuronal plasticity. In the developing brain, mature BDNF and its precursor exhibit prosurvival action through the TrkB receptor and proapoptotic functions binding to p75<jats:sup>NTR<\/jats:sup>, respectively. The aim of our experiments was to check the effects of body temperature on the postanoxic level of BDNF and on the expression of its receptors as well as on the marker of apoptosis\u2014caspase\u20103 in the rat brain. Two\u2010day\u2010old Wistar Han rats (male\/female ratio, 1:1) were exposed to anoxia in 100% nitrogen atmosphere for 10\u00a0min in different thermal conditions, which allowed them to regulate their rectal temperature at the following levels: normothermic\u201433\u00b0C; hyperthermic\u201437\u00b0C; and extremely hyperthermic\u201439\u00b0C. Thermal conditions during neonatal anoxia affected the level of proBDNF, BDNF as well as their receptors and caspase\u20103 in the forebrain. The increased BDNF protein level followed by decreased caspase\u20103 protein level was probably dependent on body temperature under anoxic conditions and was observed only in rats maintaining decreased body temperature. The positive effect of BDNF was not observed under hyperthermic conditions. Moreover, BDNF level changes correlated with body temperature probably affected the learning and spatial memory in juvenile rats.<\/jats:p>","DOI":"10.1002\/jnr.24486","type":"journal-article","created":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T03:54:56Z","timestamp":1561953296000},"page":"1266-1277","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Thermal conditions during neonatal anoxia affect the endogenous level of brain\u2010derived neurotrophic factor"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3275-6489","authenticated-orcid":false,"given":"Hanna","family":"Kletkiewicz","sequence":"first","affiliation":[{"name":"Department of Animal Physiology, Faculty of Biology and Environmental Protection Nicolaus Copernicus University Toru\u0144 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