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For example, EEDQ either augments or does not affect the DA agonist\u2010induced locomotor activity of preweanling rats while attenuating the locomotion of adolescent and adult rats. The twofold purpose of this study was to determine whether EEDQ would: (a) potentiate or attenuate the cocaine\u2010induced locomotor activity of preweanling, adolescent, and adult rats; and (b) alter the sensitivity of surviving D2 receptors. Rats were treated with vehicle or EEDQ (2.5 or 7.5\u00a0mg\/kg) on postnatal day (PD) 17, PD 39, and PD 84. In the behavioral experiments, saline\u2010 or cocaine\u2010induced locomotion was assessed 24\u00a0hr later. In the biochemical experiments, dorsal striatal samples were taken 24\u00a0hr after vehicle or EEDQ treatment and later assayed for NPA\u2010stimulated GTP\u03b3S receptor binding, G protein\u2010coupled receptor kinase 6 (GRK6), and \u03b2\u2010arrestin\u20102 (ARRB2). GTP\u03b3S binding is a direct measure of ligand\u2010induced G protein activation, while GRK6 and ARRB2 modulate the internalization and desensitization of D2 receptors. Results showed that EEDQ potentiated the locomotor activity of preweanling rats, while attenuating the locomotion of older rats. NPA\u2010stimulated GTP\u03b3S binding was elevated in EEDQ\u2010treated preweanling rats, relative to adults, indicating enhanced functional coupling between the G protein and receptor. EEDQ also reduced ARRB2 levels in all age groups, which is indicative of increased D2 receptor sensitivity. In sum, the present results support the hypothesis that D2 receptor supersensitivity is a critical factor mediating the locomotor potentiating effects of EEDQ in cocaine\u2010treated preweanling rats.<\/jats:p>","DOI":"10.1002\/jnr.24491","type":"journal-article","created":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T08:19:48Z","timestamp":1563178788000},"page":"1546-1558","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Age\u2010dependent effects of dopamine receptor inactivation on cocaine\u2010induced behaviors in male rats: Evidence of dorsal striatal D2 receptor supersensitivity"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8884-562X","authenticated-orcid":false,"given":"Cynthia A.","family":"Crawford","sequence":"first","affiliation":[{"name":"Department of Psychology California State University San Bernardino 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