{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:44:42Z","timestamp":1789764282654,"version":"4.0.1"},"reference-count":211,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T00:00:00Z","timestamp":1563148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["FDN-143210"],"award-info":[{"award-number":["FDN-143210"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009836","name":"Huntington Society of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2019,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Dopamine signaling in the striatum is critical for a variety of behaviors including movement, behavioral flexibility, response to reward and many forms of learning. Alterations to dopamine transmission contribute to pathological features of many neurological diseases, including Huntington's disease (HD). HD is an autosomal dominant genetic disorder caused by a CAG repeat expansion in the\n                    <jats:italic>Huntingtin<\/jats:italic>\n                    gene. The striatum is preferentially degenerated in HD, and this region receives dopaminergic input from the substantia nigra. Studies of HD patients and genetic rodent models have shown changes to levels of dopamine and its receptors in the striatum, and alterations in dopamine receptor signaling and modulation of other neurotransmitters, notably glutamate. Throughout his career, Dr. Michael Levine's research has furthered our understanding of dopamine signaling in the striatum of healthy rodents and HD mouse models. This review will focus on the work of his group and others in elucidating alterations to striatal dopamine signaling that contribute to pathophysiology in HD mouse models, and how these findings relate to human HD studies. We will also discuss current and potential therapeutic interventions for HD that target the dopamine system, and future research directions for this field.\n                  <\/jats:p>","DOI":"10.1002\/jnr.24495","type":"journal-article","created":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T04:23:42Z","timestamp":1563164622000},"page":"1636-1654","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":66,"title":["Dysfunctional striatal dopamine signaling in Huntington's disease"],"prefix":"10.1002","volume":"97","author":[{"given":"Ellen T.","family":"Koch","sequence":"first","affiliation":[{"name":"Department of Psychiatry University of British Columbia Vancouver BC Canada"},{"name":"Djavad Mowafaghian Centre for Brain Health University of British Columbia Vancouver BC Canada"},{"name":"Graduate Program in Neuroscience University of British Columbia Vancouver BC Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8610-1042","authenticated-orcid":false,"given":"Lynn A.","family":"Raymond","sequence":"additional","affiliation":[{"name":"Department of Psychiatry University of British Columbia Vancouver BC Canada"},{"name":"Djavad Mowafaghian Centre for Brain Health University of British Columbia Vancouver BC 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