{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T04:14:02Z","timestamp":1779250442428,"version":"3.51.4"},"reference-count":56,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T00:00:00Z","timestamp":1563148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["012302"],"award-info":[{"award-number":["012302"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["016641"],"award-info":[{"award-number":["016641"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","award":["016545"],"award-info":[{"award-number":["016545"]}],"id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Age\u2010related hearing loss (ARHL) is a neurodegenerative disorder characterized by a gradual decrease in hearing sensitivity. Previous electrophysiological and behavioral studies have demonstrated that the CBA\/CaJ mouse strain is an appropriate model for the late\u2010onset hearing loss found in humans. However, few studies have characterized hearing in these mice behaviorally using longitudinal methodologies. The goal of this research was to utilize a longitudinal design and operant conditioning procedures with positive reinforcement to construct audiograms and temporal integration functions in aging CBA\/CaJ mice. In the first experiment, thresholds were collected for 8, 16, 24, 42, and 64\u00a0kHz pure tones in 30 male and 35 female CBA\/CaJ mice. Similar to humans, mice had higher thresholds for high frequency tones than for low frequency pure tones across the lifespan. Female mice had better hearing acuity than males after 645\u00a0days of age. In the second experiment, temporal integration functions were constructed for 18 male and 18 female mice for 16 and 64\u00a0kHz tones varying in duration. Mice showed an increase in thresholds for tones shorter than 200\u00a0ms, reaching peak performance at shorter durations than other rodent species. Overall, CBA\/CaJ mice experience ARHL for pure tones of different frequencies and durations, making them a good model for studies on hearing loss. These findings highlight the importance of using a wide range of stimuli and a longitudinal design when comparing presbycusis across different species.<\/jats:p>","DOI":"10.1002\/jnr.24496","type":"journal-article","created":{"date-parts":[[2019,7,15]],"date-time":"2019-07-15T08:24:37Z","timestamp":1563179077000},"page":"1731-1744","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The effects of age and sex on the detection of pure tones by adult CBA\/CaJ mice (<i>Mus musculus<\/i>)"],"prefix":"10.1002","volume":"98","author":[{"given":"Anastasiya","family":"Kobrina","sequence":"first","affiliation":[{"name":"Department of Psychology University at Buffalo SUNY Buffalo New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7462-501X","authenticated-orcid":false,"given":"Micheal L.","family":"Dent","sequence":"additional","affiliation":[{"name":"Department of Psychology University at Buffalo SUNY Buffalo New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/occmed\/51.4.245"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.1518697"},{"key":"e_1_2_12_4_1","doi-asserted-by":"crossref","unstructured":"Bates D. M\u00e4chler M. Bolker B. &Walker S.(2014). Fitting linear mixed\u2010effects models using lme4.arXiv preprint arXiv:1406.5823.","DOI":"10.18637\/jss.v067.i01"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2000.84.4.1790"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0197774"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.395329"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(98)00103-8"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-92495-3_4"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00622976"},{"key":"e_1_2_12_11_1","first-page":"179","article-title":"Development of absolute auditory thresholds in the house mouse (Mus musculus)","volume":"1","author":"Ehret G.","year":"1976","journal-title":"Ear and Hearing"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.381030"},{"key":"e_1_2_12_13_1","volume-title":"Hearing in vertebrates: A psychophysics databook","author":"Fay R. R.","year":"1988"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.396964"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489109137382"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67423-5"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2006.12.002"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2009.09.009"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1201\/9781420038736.ch2"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.2949518"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.1911714"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(03)00401-5"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1964-09.2010"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/lary.26150"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-010-1270-7"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.3758\/BF03192744"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2016.08.014"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beproc.2018.01.009"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2845-09.2009"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489109138418"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.3569712"},{"key":"e_1_2_12_32_1","volume-title":"Age\u2010related hearing loss","author":"National Institute on Deafness and Other Communication Disorders, National Institute of Health","year":"2016"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.03.017"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.02.079"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-010-0228-1"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10162-016-0589-1"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2015.12.024"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.412231"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.2149837"},{"key":"e_1_2_12_40_1","first-page":"28","article-title":"Types and functions of ultrasonic vocalizations in laboratory rats and mice","volume":"46","author":"Portfors C. V.","year":"2007","journal-title":"Journal of the American Association for Laboratory Animal Science"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(03)00211-9"},{"key":"e_1_2_12_42_1","volume-title":"R: A language and environment for statistical computing","author":"R Core Team","year":"2014"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beproc.2014.04.016"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00359-009-0472-1"},{"key":"e_1_2_12_45_1","volume-title":"Pathology of the ear","author":"Schuknecht H. F.","year":"1974"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894931020S101"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1783-13.2013"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.3342\/ceo.2009.2.4.169"},{"key":"e_1_2_12_49_1","volume-title":"Mouse genetics: Concepts and applications","author":"Silver L. M.","year":"1995"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.399727"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(01)00305-9"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/2041-210X.12797"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.3109\/14992020309078340"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.1911819"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2016.2661"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.12.011"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(99)00003-9"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.24496","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.24496","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jnr.24496","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.24496","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T08:59:53Z","timestamp":1693904393000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.24496"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,15]]},"references-count":56,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1002\/jnr.24496"],"URL":"https:\/\/doi.org\/10.1002\/jnr.24496","archive":["Portico"],"relation":{},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,15]]},"assertion":[{"value":"2019-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-06-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-07-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}