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Failures in BDNF supply and mitochondrial dysfunction are among the factors involved in the striatal degeneration that occurs in Huntington's disease (HD). While the effects of BDNF have been widely studied in striatal degeneration, the role of NT\u20104\/5 has been less addressed. NT\u20104\/5 does not appear to exert effects similar to those of BDNF in HD. The physiological roles of these molecules in corticostriatal transmission have been evaluated separately, and we have demonstrated that sequential exposure to both neurotrophins results in different modulatory effects on corticostriatal transmission depending on the exposure order. In the present study, we evaluated the effects of BDNF followed by NT\u20104\/5 or NT\u20104\/5 followed by BDNF on corticostriatal synaptic transmission with field recordings in a male mouse model of HD produced by <jats:italic>in vivo<\/jats:italic> treatment with the mitochondrial toxin 3\u2010nitropropionic acid. Here, we show that these neurotrophins elicit an antagonistic or synergistic effect that depends on the activation of the truncated isoform or the stimulation of the full\u2010length isoform of the tropomyosin receptor kinase B.<\/jats:p>","DOI":"10.1002\/jnr.24507","type":"journal-article","created":{"date-parts":[[2019,8,8]],"date-time":"2019-08-08T04:24:40Z","timestamp":1565238280000},"page":"1665-1677","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Do BDNF and NT\u20104\/5 exert synergistic or occlusive effects on corticostriatal transmission in a male mouse model of Huntington's disease?"],"prefix":"10.1002","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2320-202X","authenticated-orcid":false,"given":"Francisco M.","family":"Torres\u2010Cruz","sequence":"first","affiliation":[{"name":"Laboratorio de Neurofisiolog\u00eda del desarrollo y la neurodegeneraci\u00f3n, Unidad de Investigaci\u00f3n en Biomedicina FES\u2010Iztacala Universidad Nacional Aut\u00f3noma de M\u00e9xico M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto","family":"Mendoza","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofisiolog\u00eda del desarrollo y la neurodegeneraci\u00f3n, Unidad de Investigaci\u00f3n en Biomedicina FES\u2010Iztacala Universidad Nacional Aut\u00f3noma de M\u00e9xico M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel C.","family":"Vivar\u2010Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofisiolog\u00eda del desarrollo y la neurodegeneraci\u00f3n, Unidad de Investigaci\u00f3n en Biomedicina FES\u2010Iztacala Universidad Nacional Aut\u00f3noma de M\u00e9xico M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Garc\u00eda\u2010Sierra","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda Celular CINVESTAV Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2910-9248","authenticated-orcid":false,"given":"Elizabeth","family":"Hern\u00e1ndez\u2010Echeagaray","sequence":"additional","affiliation":[{"name":"Laboratorio de Neurofisiolog\u00eda del desarrollo y la neurodegeneraci\u00f3n, Unidad de Investigaci\u00f3n en Biomedicina FES\u2010Iztacala Universidad Nacional Aut\u00f3noma de M\u00e9xico M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.74.9.3767"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(98)01273-9"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00797.2007"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(94)91333-1"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-18-05661.1996"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.13-10-04181.1993"},{"issue":"8","key":"e_1_2_11_8_1","doi-asserted-by":"crossref","first-page":"2461","DOI":"10.1242\/dev.121.8.2461","article-title":"Selective binding and internalisation by truncated receptors restrict the availability of BDNF during development","volume":"121","author":"Biffo S.","year":"1995","journal-title":"Development"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-0082(99)00005-2"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1999.tb00216.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-03-00961.2003"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.30501"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)50574-3"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.06.032"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0887-2333(89)90034-9"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-04-01374.2000"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.16-10-03123.1996"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12264-012-1259-x"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/73921"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2004.06.018"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2006.04590.x"},{"issue":"3","key":"e_1_2_11_22_1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1101\/lm.6.3.243","article-title":"Signaling mechanisms mediating BDNF modulation of synaptic plasticity in the hippocampus","volume":"6","author":"Gottschalk W. 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