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Current therapy for infants suffering from premature brain injury is still mainly supportive, and there are no effective treatments. Thus there is a pressing need for comparative and translational studies on how to reduce brain injury and to increase regeneration and brain repair in preterm infants. There is strong supporting evidence for the use of umbilical cord blood (UCB)\u2010derived stem cell therapy for treating preterm brain injury and neurological sequelae. UCB\u2010derived stem cell therapy is effective in many animal models and has been shown to be feasible in clinical trials. Most of these therapies are still experimental, however. In this review, we focus on recent advances on the efficacy of UCB\u2010derived stem cell therapy in preterm infants with brain injury, and discuss the potential mechanisms behind their therapeutic effects as well as application strategies for future preclinical and clinical trials.<\/jats:p>","DOI":"10.1002\/jnr.24548","type":"journal-article","created":{"date-parts":[[2019,12,4]],"date-time":"2019-12-04T07:39:34Z","timestamp":1575445174000},"page":"815-825","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Umbilical cord blood stem cell therapy in premature brain injury: Opportunities and challenges"],"prefix":"10.1002","volume":"98","author":[{"given":"Xirui","family":"Peng","sequence":"first","affiliation":[{"name":"Henan Key Laboratory of Child Brain Injury Institute of Neuroscience and Third Affiliated Hospital, Zhengzhou University Zhengzhou 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