{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:02:13Z","timestamp":1790193733156,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,1,27]],"date-time":"2020-01-27T00:00:00Z","timestamp":1580083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Age\u2010related hearing loss (ARHL) has recently been confirmed as a common complex trait, that is, it is heritable with many genetic variants each contributing a small amount of risk, as well as environmental determinants. Historically, attempts to identify the genetic variants underlying the ARHL have been of limited success, relying on the selection of candidate genes based on the limited knowledge of the pathophysiology of the condition, and linkage studies in samples comprising related individuals. More recently genome\u2010wide association studies have been performed, but these require very large samples having consistent and reliable phenotyping for hearing loss (HL), and early attempts suffered from lack of reliable replication of their findings. Replicated variants shown associated with ARHL include those lying in genes <jats:italic>GRM7<\/jats:italic>, <jats:italic>ISG20<\/jats:italic>, <jats:italic>TRIOBP<\/jats:italic>,<jats:italic> ILDR1<\/jats:italic>, and <jats:italic>EYA4.<\/jats:italic> The availability of large biobanks and the development of collaborative consortia have led to a breakthrough over the last couple of years, and many new genetic variants associated with ARHL are becoming available, through the analysis publicly available bioresources and electronic health records. These findings along with immunohistochemistry and mouse models of HL look set to help disentangle the genetic architecture of ARHL, and highlight the need for standardization of phenotyping methods to facilitate data sharing and collaboration across research networks.<\/jats:p>","DOI":"10.1002\/jnr.24549","type":"journal-article","created":{"date-parts":[[2020,1,28]],"date-time":"2020-01-28T07:12:11Z","timestamp":1580195531000},"page":"1698-1704","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Genetics of age\u2010related hearing loss"],"prefix":"10.1002","volume":"98","author":[{"given":"Helena Rose Rees","family":"Wells","sequence":"first","affiliation":[{"name":"Department of Twin Research and Genetic Epidemiology King\u2019s College London London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tracey A.","family":"Newman","sequence":"additional","affiliation":[{"name":"CES, Medicine, B85, M55, Life Sciences University of Southampton Southampton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2998-2744","authenticated-orcid":false,"given":"Frances M. 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