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Intracerebroventricular administration of NPY induces increases in food intake and alters feeding rate. Besides it role in feeding behavior, NPY also has significant effects on neuronal systems related to other spontaneous behaviors such as rearing and grooming. In the present study, we examined the direct effects of NPY on mesencephalic V neurons (Mes V), which are important sensory neurons involved in oral motor reflexes and rhythmical jaw movements, as well as masticatory proprioception. Coronal brain slices were prepared from neonatal Sprague\u2010Dawley rats (P3\u201017) and whole\u2010cell patch clamp recordings were obtained from Mes V neurons. Bath application of NPY depolarized the membrane potential and induced inward current in most neurons. Application of NPY shortened the duration of the afterhyperpolarization following an action potential, and increased the mean spike frequency during repetitive discharge. In those neurons which exhibited rhythmical burst discharge in response to maintained current injection, the bursting frequency was also increased. These effects were mediated predominately by both Y1 and Y5 receptors.<\/jats:p>","DOI":"10.1002\/jnr.24583","type":"journal-article","created":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T04:21:31Z","timestamp":1579494091000},"page":"921-935","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Neuropeptide Y modulates membrane excitability in neonatal rat mesencephalic V neurons"],"prefix":"10.1002","volume":"98","author":[{"given":"Soju","family":"Seki","sequence":"first","affiliation":[{"name":"The 1st Department of Oral and Maxillofacial Surgery Graduate School of Dentistry Osaka University Suita Japan"},{"name":"Department of Integrative Biology and Physiology and the Brain Research Institute University of California Los Angeles CA 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