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Of specific interest for this review are L\u2010type voltage\u2010dependent Ca<jats:sup>2+<\/jats:sup>channels (L\u2010VDCCs), due to their pleiotropic role in several CNS disorders. Currently, there are numerous approved drugs that target L\u2010VDCCs, including dihydropyridines. These drugs are safe and effective for the treatment of humans with cardiovascular disease and may also confer neuroprotection. Here, we review the potential of L\u2010VDCCs as a target for the treatment of CNS disorders with a focus on microglia L\u2010VDCCs. Microglia, the resident immune cells of the brain, have attracted recent attention for their emerging inflammatory role in several CNS diseases. Intracellular Ca<jats:sup>2+<\/jats:sup>regulates microglia transition from a resting quiescent state to an \u201cactivated\u201d immune\u2010effector state and is\u00a0thus a valuable target for manipulation of microglia phenotype. We will review the literature on L\u2010VDCC expression and function in the CNS and on microglia<jats:italic>in vitro<\/jats:italic>and<jats:italic>in vivo<\/jats:italic>and explore the therapeutic landscape of L\u2010VDCC\u2010targeting agents at present and future challenges in the context of Alzheimer's disease, Parkinson's disease, Huntington's disease, neuropsychiatric diseases, and other CNS disorders.<\/jats:p>","DOI":"10.1002\/jnr.24585","type":"journal-article","created":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T05:42:58Z","timestamp":1580362978000},"page":"141-162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":45,"title":["Targeting microglia L\u2010type voltage\u2010dependent calcium channels for the treatment of central nervous system disorders"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5228-0022","authenticated-orcid":false,"given":"Sarah 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