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With disease and\/or age, hormone expression begins to decline drastically, which ultimately affects cochlear structures and the integrity of cochlear cells. The following review explores the latest findings as well as realistic outcomes for hormone therapy treatment in the auditory system. This information could serve as a potential guide for patients considering hormone therapy as a medicinal choice to alleviate the signs of onset of presbycusis\u2014age\u2010related hearing loss. Additional scientific investigations could also be carried out to further enhance recent findings.<\/jats:p>","DOI":"10.1002\/jnr.24588","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T04:27:00Z","timestamp":1580963220000},"page":"1721-1730","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Understanding hormone and hormone therapies' impact on the auditory system"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2347-2241","authenticated-orcid":false,"given":"Tanika T.","family":"Williamson","sequence":"first","affiliation":[{"name":"Department of Medical Engineering Global Center for Hearing &amp; Speech Research University of South Florida Tampa FL USA"},{"name":"Department of Chemical &amp; Biological Engineering Global Center for Hearing &amp; Speech Research University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Medical Engineering Global Center for Hearing &amp; Speech Research University of South Florida Tampa FL USA"},{"name":"Department of Chemical &amp; Biological Engineering Global Center for Hearing &amp; Speech Research University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Pineros","sequence":"additional","affiliation":[{"name":"Department of Medical Engineering Global Center for Hearing &amp; Speech Research University of South Florida Tampa FL USA"},{"name":"Department of Chemical &amp; Biological Engineering Global Center for Hearing &amp; Speech Research University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Communication Sciences &amp; Disorders Global Center for Hearing &amp; Speech Research University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Frisina","sequence":"additional","affiliation":[{"name":"Department of Medical Engineering Global Center for Hearing &amp; Speech Research University of South Florida Tampa FL USA"},{"name":"Department of Chemical &amp; Biological Engineering Global Center for Hearing &amp; Speech Research University of South Florida Tampa FL USA"},{"name":"Department of Communication Sciences &amp; Disorders Global Center for Hearing &amp; Speech Research University of South Florida Tampa FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.00378"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.02.077"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2010.05.007"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1590\/2359-3997000000292"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3856"},{"issue":"2","key":"e_1_2_11_7_1","first-page":"99","article-title":"The effect of topical estrogen on healing of chronic tympanic membrane perforations and hearing threshold","volume":"18","author":"Barati B.","year":"2013","journal-title":"Journal of Research in Medical Sciences"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2430-11.2011"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2015.04.020"},{"key":"e_1_2_11_10_1","volume-title":"Biochemistry","author":"Berg J. 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