{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:47:28Z","timestamp":1786978048797,"version":"build-2736575974"},"reference-count":205,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T00:00:00Z","timestamp":1581638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30GM114750,1R21NS095130, 1R21NS096525, R44 NS0845"],"award-info":[{"award-number":["P30GM114750,1R21NS095130, 1R21NS096525, R44 NS0845"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Perinatal hypoxic\u2010ischemic (HI)\u2010related brain injury is an important cause of morbidity and long\u2010standing disability in newborns. The only currently approved therapeutic strategy available to reduce brain injury in the newborn is hypothermia. Therapeutic hypothermia can only be used to treat HI encephalopathy in full\u2010term infants and survivors remain at high risk for a wide spectrum of neurodevelopmental abnormalities as a result of residual brain injury. Therefore, there is an urgent need for adjunctive therapeutic strategies. Inflammation and neurovascular damage are important factors that contribute to the pathophysiology of HI\u2010related brain injury and represent exciting potential targets for therapeutic intervention. In this review, we address the role of each component of the neurovascular unit (NVU) in the pathophysiology of HI\u2010related injury in the neonatal brain. Disruption of the blood\u2013brain barrier (BBB) observed in the early hours after an HI\u2010related event is associated with a response at the basal lamina level, which comprises astrocytes, pericytes, and immune cells, all of which could affect BBB function to further exacerbate parenchymal injury. Future research is required to determine potential drugs that could prevent or attenuate neurovascular damage and\/or augment repair. However, some studies have reported beneficial effects of hypothermia, erythropoietin, stem cell therapy, anti\u2010cytokine therapy and metformin in ameliorating several different facets of damage to the NVU after HI\u2010related brain injury in the perinatal period.<\/jats:p>","DOI":"10.1002\/jnr.24590","type":"journal-article","created":{"date-parts":[[2020,2,14]],"date-time":"2020-02-14T23:34:25Z","timestamp":1581723265000},"page":"1468-1484","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Hypoxic\u2010ischemic\u2010related cerebrovascular changes and potential therapeutic strategies in the neonatal brain"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3107-3459","authenticated-orcid":false,"given":"Cl\u00e9mence","family":"Disdier","sequence":"first","affiliation":[{"name":"Department of Pediatrics Women &amp; Infants Hospital of Rhode Island The Alpert Medical School of Brown University Providence RI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6532-7683","authenticated-orcid":false,"given":"Barbara S.","family":"Stonestreet","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Women &amp; Infants Hospital of Rhode Island The Alpert Medical School of Brown University Providence RI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,14]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.2002.00064.x"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03696.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2010.148"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1503497112"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0029-1220793"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-006-0232-z"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI60842"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808698106"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.10242"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-200112000-00003"},{"issue":"11","key":"e_1_2_10_12_1","first-page":"1056","article-title":"Moderate hypothermia to treat perinatal asphyxial encephalopathy (vol 361, pg 1349, 2009)","volume":"362","author":"Azzopardi D. V.","year":"2010","journal-title":"New England Journal of Medicine"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2012.191"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2012.00424"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2012.09.007"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrdd.20107"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2015.04.006"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24132"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3180db291b"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2006.12.014"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2003.12.016"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000180535.14093.FB"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1011965307612"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000264398"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1159\/000097202"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1523\/ENEURO.0123-18.2018"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlz051"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000144819.45689.BB"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(93)90031-5"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2009.02.062"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3904"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2010.05.003"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2015.01.004"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12033"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19010061"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.05.002"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/289519"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06362.x"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1159\/000489700"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.09.007"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2012.08.043"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17081249"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00171-3"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2007.01.014"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1080\/02699050802403565"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.114.007145"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0847-6"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0013741"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09513"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2006.07.056"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920011798357024"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2001.6117"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci8060101"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-3782(79)90022-7"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1006907608230"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(03)00558-X"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.2174\/138161208784705469"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60761-938-3_2"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1006\/mvre.2000.2244"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cryobiol.2007.08.009"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(03)02401-6"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2014.255"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2015.06.047"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2011.12.009"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20885"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.10661"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2010.04.025"},{"issue":"1","key":"e_1_2_10_68_1","first-page":"15","article-title":"Drug metabolizing enzymes in cerebrovascular endothelial cells afford a metabolic protection to the brain","volume":"45","author":"El\u2010Bacha R. S.","year":"1999","journal-title":"Cellular and Molecular Biology"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-8118-12-4"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0205769"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-018-0053-3"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.20779"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2009.07.011"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2102-11.2011"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2012.187"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22358"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra041996"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-279"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.22487"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.57.5.774"},{"issue":"15","key":"e_1_2_10_81_1","first-page":"1644","article-title":"Hypothermia for neonates with hypoxic\u2010ischemic encephalopathy","volume":"354","author":"Gluckman P. D.","year":"2006","journal-title":"New England Journal of Medicine"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1006\/mvre.2002.2413"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2008.07.003"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17732229"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22620"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1159\/000069040"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.13"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13165"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000116866.60794.21"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp300334r"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.57.2.4"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16630991"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.110.14.1603"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-6363(96)00063-6"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2013.244"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12683"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.07.030"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18112356"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bht246"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2014.03.003"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.549691"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720208783565645"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1111\/dmcn.13215"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-10-0377"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nurt.2010.07.006"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2009.04.004"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(96)00117-4"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X18797328"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2008-0269"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2016.10.022"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5360-06.2007"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2015.119"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2005.103.2.0289"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-0867-5"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-5-34"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2013.89"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1166\/jnn.2014.8728"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X18814614"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(91)90784-S"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18071356"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.05.034"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2007.05.043"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2018.01.023"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2012.03637.x"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.20990"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-3806(94)00177-2"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2017.00078"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.acr.2014.10.002"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.07.007"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11596-0"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00040"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2003.08.020"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2018.07.007"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0497-x"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.11.2281"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2017.260"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.12.002"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.3390\/children5070099"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-007-9195-4"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2016.09.007"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22419"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2005.07.003"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2006.08.004"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.309823.117"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(99)00125-X"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2014-1566"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.12.051"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2011.59"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.06.011"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-004-0905-4"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600385"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0814fje"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.07.069"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.021908.132528"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410090206"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01724.x"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2016.00057"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2015.134"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2012.00046"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0330-8"},{"issue":"7","key":"e_1_2_10_161_1","doi-asserted-by":"crossref","first-page":"3340","DOI":"10.4049\/jimmunol.161.7.3340","article-title":"Generation of biologically active IL\u20101 beta by matrix metalloproteinases: A novel caspase\u20101\u2010independent pathway of IL\u20101 beta processing","volume":"161","author":"Schonbeck U.","year":"1998","journal-title":"Journal of Immunology"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1998.70031151.x"},{"issue":"11","key":"e_1_2_10_163_1","first-page":"1073","article-title":"Childhood outcomes after hypothermia for neonatal encephalopathy (vol 366, pg 2085, 2012)","volume":"367","author":"Shankaran S.","year":"2012","journal-title":"New England Journal of Medicine"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcps050929"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp200129p"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.109.564229"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2018.02.020"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1111\/fcp.12175"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3898"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1676"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2000.tb00248.x"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2015.00021"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2010.01.010"},{"key":"e_1_2_10_174_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4391-06.2007"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2011.1772"},{"key":"e_1_2_10_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2013.03.036"},{"key":"e_1_2_10_177_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2016.178"},{"key":"e_1_2_10_178_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2015.47"},{"key":"e_1_2_10_179_1","doi-asserted-by":"publisher","DOI":"10.1159\/000288265"},{"key":"e_1_2_10_180_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22518"},{"key":"e_1_2_10_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(88)90275-2"},{"key":"e_1_2_10_182_1","doi-asserted-by":"publisher","DOI":"10.1159\/000047185"},{"key":"e_1_2_10_183_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.629931"},{"key":"e_1_2_10_184_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-8-40"},{"key":"e_1_2_10_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2008.04.007"},{"key":"e_1_2_10_186_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awl318"},{"key":"e_1_2_10_187_1","doi-asserted-by":"publisher","DOI":"10.1053\/sp.2000.6361"},{"key":"e_1_2_10_188_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00418-004-0665-1"},{"key":"e_1_2_10_189_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-006-9061-x"},{"key":"e_1_2_10_190_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0000000000000071"},{"key":"e_1_2_10_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-3806(00)00086-9"},{"key":"e_1_2_10_192_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000070112.80711.3D"},{"key":"e_1_2_10_193_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00247-012-2373-7"},{"key":"e_1_2_10_194_1","doi-asserted-by":"publisher","DOI":"10.1038\/jcbfm.2008.32"},{"key":"e_1_2_10_195_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207454.2014.966354"},{"key":"e_1_2_10_196_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.111.000719"},{"key":"e_1_2_10_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2016.09.024"},{"key":"e_1_2_10_198_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00136.2018"},{"key":"e_1_2_10_199_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs115"},{"key":"e_1_2_10_200_1","doi-asserted-by":"publisher","DOI":"10.1159\/000346323"},{"key":"e_1_2_10_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.braindev.2018.08.007"},{"key":"e_1_2_10_202_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-258822"},{"key":"e_1_2_10_203_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2016.02.020"},{"key":"e_1_2_10_204_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X18808174"},{"key":"e_1_2_10_205_1","doi-asserted-by":"publisher","DOI":"10.1159\/000362262"},{"key":"e_1_2_10_206_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2008.01.003"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fjnr.24590","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.24590","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jnr.24590","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.24590","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T06:59:49Z","timestamp":1693205989000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.24590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,14]]},"references-count":205,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2020,7]]}},"alternative-id":["10.1002\/jnr.24590"],"URL":"https:\/\/doi.org\/10.1002\/jnr.24590","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JNR.24590\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.24590\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.24590\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.24590\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.24590\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.24590\/v3\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.24590\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.24590\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.24590\/v3\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.24590\/v2\/response1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.24590\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,14]]},"assertion":[{"value":"2019-09-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-28","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-14","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}