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Evidence suggests that the strength and distribution of this intermuscular inhibition is dependent on motor task and corresponding signals from the brainstem. The purpose of the present study was to investigate whether this sensory network is altered after spinal cord hemisection as a potential explanation for motor deficits observed after spinal cord injury (SCI). Force feedback was assessed between the long toe flexor and ankle plantarflexor (flexor hallucis longus), and the three major ankle extensors, (combined gastrocnemius, soleus, and plantaris muscles) in the hind limbs of unanesthetized, decerebrate, female cats. Data were collected from animals with intact spinal cords (control) and lateral spinal hemisections (LSHs) including chronic LSH (4\u201320 weeks), subchronic LSH (2\u00a0weeks), and acute LSH. Muscles were stretched individually and in pairwise combinations to measure intermuscular feedback between the toe flexor and each of the ankle extensors. In control animals, three patterns were observed (balanced inhibition between toe flexor and ankle extensors, stronger inhibition from toe flexor to ankle extensor, and vice versa). Following spinal hemisection, only strong inhibition from toe flexors onto ankle extensors was observed independent of survival time. The results suggest immediate and permanent reorganization of force feedback in the injured spinal cord. The altered strength and distribution of force feedback after SCI may be an important future target for rehabilitation.<\/jats:p>","DOI":"10.1002\/jnr.24630","type":"journal-article","created":{"date-parts":[[2020,6,14]],"date-time":"2020-06-14T21:44:56Z","timestamp":1592171096000},"page":"1646-1661","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Redistribution of inhibitory force feedback between a long toe flexor and the major ankle extensor muscles following spinal cord injury"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8502-1788","authenticated-orcid":false,"given":"Irrum F.","family":"Niazi","sequence":"first","affiliation":[{"name":"School of Biological Sciences Georgia Institute of Technology Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0954-0447","authenticated-orcid":false,"given":"Mark A.","family":"Lyle","sequence":"additional","affiliation":[{"name":"Division of Physical Therapy Department of Rehabilitation Medicine Emory University Atlanta GA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0725-9758","authenticated-orcid":false,"given":"Aaron","family":"Rising","sequence":"additional","affiliation":[{"name":"Kentucky Spinal Cord Injury Research Center Department of Neurological Surgery University of Louisville Louisville KY USA"},{"name":"Robley Rex VA Medical Center Louisville KY USA"},{"name":"National Eye Institute National Institutes of Health Bethesda MD USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7277-2550","authenticated-orcid":false,"given":"Dena R.","family":"Howland","sequence":"additional","affiliation":[{"name":"Kentucky Spinal Cord Injury Research Center Department of Neurological Surgery University of Louisville Louisville KY USA"},{"name":"Robley Rex VA Medical Center Louisville KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0605-4953","authenticated-orcid":false,"given":"T. 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