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Instead, a focus on the opioid receptor as the ultimate molecular target to directly abolish opioid overdose death is explored. After identifying the key brainstem neurons that control respiration which are inhibited by opioid drugs, genetic techniques targeting the\n                    <jats:italic>mu<\/jats:italic>\n                    opioid receptor are detailed which prevent opioid overdose. This receptor\u2010centric solution for the opioid overdose epidemic can be realized with existing technology and, with sufficient effort, could enter clinical trials within 5 to 10\u00a0years.\n                  <\/jats:p>","DOI":"10.1002\/jnr.24636","type":"journal-article","created":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T08:16:46Z","timestamp":1589789806000},"page":"322-328","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Receptor\u2010centric solutions for the opioid epidemic: Making the opioid user impervious to overdose death"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4936-2999","authenticated-orcid":false,"given":"Craig W.","family":"Stevens","sequence":"first","affiliation":[{"name":"Department of Pharmacology &amp; Physiology Center for Health Sciences Oklahoma State University  Tulsa OK USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,18]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2018.304881"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(03)00002-8"},{"key":"e_1_2_10_4_1","unstructured":"Council of Economic Advisors. 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