{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T18:09:24Z","timestamp":1788545364749,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T00:00:00Z","timestamp":1589587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Jianxin Bao","award":["DC010489"],"award-info":[{"award-number":["DC010489"]}]},{"name":"Jianxin Bao","award":["DC011793"],"award-info":[{"award-number":["DC011793"]}]},{"name":"Nancy Tye-Murray","award":["AG-018029"],"award-info":[{"award-number":["AG-018029"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Deleterious age\u2010related changes in the central auditory nervous system have been referred to as central age\u2010related hearing impairment (ARHI) or central presbycusis. Central ARHI is often assumed to be the consequence of peripheral ARHI. However, it is possible that certain aspects of central ARHI are independent from peripheral ARHI. A confirmation of this possibility could lead to significant improvements in current rehabilitation practices. The major difficulty in addressing this issue arises from confounding factors, such as other age\u2010related changes in both the cochlea and central non\u2010auditory brain structures. Because gap detection is a common measure of central auditory temporal processing, and gap detection thresholds are less influenced by changes in other brain functions such as learning and memory, we investigated the potential relationship between age\u2010related peripheral hearing loss (i.e., audiograms) and age\u2010related changes in gap detection. Consistent with previous studies, a significant difference was found for gap detection thresholds between young and older adults. However, among older adults, no significant associations were observed between gap detection ability and several other independent variables including the pure tone audiogram average, the Wechsler Adult Intelligence Scale\u2010Vocabulary score, gender, and age. Statistical analyses showed little or no contributions from these independent variables to gap detection thresholds. Thus, our data indicate that age\u2010related decline in central temporal processing is largely independent of peripheral ARHI.<\/jats:p>","DOI":"10.1002\/jnr.24639","type":"journal-article","created":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T14:51:20Z","timestamp":1589640680000},"page":"1800-1814","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Evidence for independent peripheral and central age\u2010related hearing impairment"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2399-8873","authenticated-orcid":false,"given":"Jianxin","family":"Bao","sequence":"first","affiliation":[{"name":"Department of Anatomy and Neurobiology Northeast Ohio Medical University Rootstown OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Yu","sequence":"additional","affiliation":[{"name":"The First People\u2019s Hospital of Zhangjiagang Zhangjiagang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology Northeast Ohio Medical University Rootstown OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Hawks","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology Northeast Ohio Medical University Rootstown OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grace","family":"Szatkowski","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology Northeast Ohio Medical University Rootstown OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bethany","family":"Dade","sequence":"additional","affiliation":[{"name":"Department of Anatomy and Neurobiology Northeast Ohio Medical University Rootstown OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Statistics Iowa State University Ames IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Statistics Iowa State University Ames IA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Brutnell","sequence":"additional","affiliation":[{"name":"Department of Research and Development Gateway Biotechnology Inc. 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