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Mutations in ataxin\u20103 cause spinocerebellar ataxia type 3 (SCA3), a neurodegenerative disorder that is a member of the polyglutamine family of diseases. Two major isoforms arise from alternative splicing of\n                    <jats:italic>ATXN3<\/jats:italic>\n                    and are differently toxic\n                    <jats:italic>in vivo<\/jats:italic>\n                    as a result of faster proteasomal degradation of one isoform compared to the other. The isoforms vary only at their C\u2010termini, suggesting that the hydrophobic C\u2010terminus of the more quickly degraded form of ataxin\u20103 (here referred to as isoform 2) functions as a degron\u2014that is, a peptide sequence that expedites the degradation of its host protein. We explored this notion in this study and present evidence that: (a) the C\u2010terminus of ataxin\u20103 isoform 2 signals its degradation in a proteasome\u2010dependent manner, (b) this effect from the C\u2010terminus of isoform 2 does not require the ubiquitination of ataxin\u20103, and (c) the isolated C\u2010terminus of isoform 2 can enhance the degradation of an unrelated protein. According to our data, the C\u2010terminus of ataxin\u20103 isoform 2 is a degron, increasing overall understanding of the cellular properties of the SCA3 protein.\n                  <\/jats:p>","DOI":"10.1002\/jnr.24684","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T06:14:50Z","timestamp":1594275290000},"page":"2096-2108","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Degron capability of the hydrophobic C\u2010terminus of the polyglutamine disease protein, ataxin\u20103"],"prefix":"10.1002","volume":"98","author":[{"given":"Jessica R.","family":"Blount","sequence":"first","affiliation":[{"name":"Department of Pharmacology Wayne State University School of Medicine Detroit MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sean L.","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Wayne State University School 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