{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:48:22Z","timestamp":1789663702078,"version":"4.0.1"},"reference-count":68,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T00:00:00Z","timestamp":1595203200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AG060981\u201001"],"award-info":[{"award-number":["R01 AG060981\u201001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Dynamics within and between functional resting\u2010state networks have a crucial role in determining both healthy and pathological brain functioning in humans. The possibility to noninvasively interact and selectively modulate the activity of networks would open to relevant applications in neuroscience. Here we tested a novel approach for multichannel, network\u2010targeted transcranial direct current stimulation (net\u2010tDCS), optimized to increase excitability of the sensorimotor network (SMN) while inducing cathodal inhibitory modulation over prefrontal and parietal brain regions negatively correlated with the SMN. Using an MRI\u2010compatible multichannel transcranial electrical stimulation (tES) device, 20 healthy participants underwent real and sham tDCS while at rest in the MRI scanner. Changes in functional connectivity (FC) during and after stimulation were evaluated, looking at the intrinsic FC of the SMN and the strength of the negative connectivity between SMN and the rest of the brain. Standard, bifocal tDCS targeting left motor cortex (electrode ~C3) and right frontopolar (~Fp2) regions was tested as a control condition in a separate sample of healthy subjects to investigate network specificity of multichannel stimulation effects. Net\u2010tDCS induced greater FC increase over the SMN compared to bifocal tDCS, during and after stimulation. Moreover, exploratory analysis of the impact of net\u2010tDCS on negatively correlated networks showed an increase in the negative connectivity between SMN and prefrontal\/parietal areas targeted by cathodal stimulation both during and after real net\u2010tDCS. Results suggest preliminary evidence of the possibility of manipulating distributed network connectivity patterns through net\u2010tDCS, with potential relevance for the development of cognitive enhancement and therapeutic tES solutions.<\/jats:p>","DOI":"10.1002\/jnr.24690","type":"journal-article","created":{"date-parts":[[2020,7,20]],"date-time":"2020-07-20T04:11:13Z","timestamp":1595218273000},"page":"1843-1856","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Impact of network\u2010targeted multichannel transcranial direct current stimulation on intrinsic and network\u2010to\u2010network functional connectivity"],"prefix":"10.1002","volume":"98","author":[{"given":"Lucia","family":"Mencarelli","sequence":"first","affiliation":[{"name":"Siena Brain Investigation &amp; Neuromodulation Lab (Si\u2010BIN Lab) Department of Medicine, Surgery and Neuroscience of the Siena School of Medicine, Neurology and Clinical 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