{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T14:01:42Z","timestamp":1784210502940,"version":"3.55.0"},"reference-count":60,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T00:00:00Z","timestamp":1595980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["DPA20140629794"],"award-info":[{"award-number":["DPA20140629794"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2022,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Poor sociability and aggressive behavior are key clinical features of opioid use disorders. The corticotropin\u2010releasing factor (CRF) system may mediate behavioral effects of substances of abuse\n                    <jats:italic>but<\/jats:italic>\n                    its implication in substance\u2010induced social behavior deficits and outward\u2010directed hostility remains largely unknown. CRF signaling is mediated by two receptor types, termed CRF\n                    <jats:sub>1<\/jats:sub>\n                    and CRF\n                    <jats:sub>2<\/jats:sub>\n                    . The present study aimed at understanding the role for the CRF\n                    <jats:sub>1<\/jats:sub>\n                    receptor in social and aggressive behavior induced by withdrawal from repeated opiate administration. Thus, wild\u2010type (CRF\n                    <jats:sub>1<\/jats:sub>\n                    +\/+), CRF\n                    <jats:sub>1<\/jats:sub>\n                    receptor heterozygous (CRF\n                    <jats:sub>1<\/jats:sub>\n                    +\/\u2212), and null mutant (CRF\n                    <jats:sub>1<\/jats:sub>\n                    \u2212\/\u2212) female and male mice were treated with saline or escalating doses of morphine (20\u2010100\u00a0mg\/kg, i.p.) during six consecutive days and tested in the three\u2010chamber task for sociability (i.e., preference for an unfamiliar same\u2010sex conspecific vs. an object) 7\u00a0days after the last administration. Moreover, aggressive biting behavior toward the unfamiliar conspecific was assessed during the three\u2010chamber test. Opiate withdrawal disrupted sociability in CRF\n                    <jats:sub>1<\/jats:sub>\n                    +\/+ and CRF\n                    <jats:sub>1<\/jats:sub>\n                    +\/\u2212,\n                    <jats:italic>but not<\/jats:italic>\n                    in CRF\n                    <jats:sub>1<\/jats:sub>\n                    \u2212\/\u2212, female mice, without affecting aggressive biting behavior in any genotype. In contrast, opiate withdrawal did not affect sociability\n                    <jats:italic>but<\/jats:italic>\n                    increased aggressive biting behavior in male mice, independently of CRF\n                    <jats:sub>1<\/jats:sub>\n                    receptor\u2010deficiency. Nevertheless, in opiate\u2010withdrawn CRF\n                    <jats:sub>1<\/jats:sub>\n                    +\/+,\n                    <jats:italic>but not<\/jats:italic>\n                    CRF\n                    <jats:sub>1<\/jats:sub>\n                    +\/\u2212 and CRF\n                    <jats:sub>1<\/jats:sub>\n                    \u2212\/\u2212, male mice, sociability directly correlated with aggressive biting behavior, suggesting a role for the CRF\n                    <jats:sub>1<\/jats:sub>\n                    receptor in hostility\u2010linked social approach. These findings demonstrate the implication of the CRF\n                    <jats:sub>1<\/jats:sub>\n                    receptor in social behavior deficits associated with repeated opiate administration and withdrawal, revealing a new potential target for the treatment of opioid use disorders.\n                  <\/jats:p>","DOI":"10.1002\/jnr.24697","type":"journal-article","created":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T03:20:15Z","timestamp":1595992815000},"page":"309-321","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["The CRF\n                    <sub>1<\/sub>\n                    receptor mediates social behavior deficits induced by opiate withdrawal"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9566-3808","authenticated-orcid":false,"given":"Alessandro","family":"Piccin","sequence":"first","affiliation":[{"name":"Universit\u00e9 de Bordeaux, INCIA, UMR 5287  Bordeaux France"},{"name":"CNRS, INCIA, UMR 5287  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7286-6941","authenticated-orcid":false,"given":"Angelo","family":"Contarino","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Bordeaux, INCIA, UMR 5287  Bordeaux France"},{"name":"CNRS, INCIA, UMR 5287  Bordeaux France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1976.01770030067010"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2017.03.003"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23963"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2014.01.022"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2017.08.012"},{"key":"e_1_2_12_8_1","volume-title":"Statistical power analysis for the behavioral sciences","author":"Cohen J.","year":"1988"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0006\u20108993(98)01158\u20105"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.141.7.7653"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.01.024"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506999102"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/1874467210666170302104053"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1049\u201010.2010"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306\u20104530(01)00073\u20107"},{"key":"e_1_2_12_16_1","volume-title":"European Monitoring Centre for Drugs and Drug Addiction. 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