{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T14:33:20Z","timestamp":1780583600229,"version":"3.54.1"},"reference-count":99,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,8,4]],"date-time":"2020-08-04T00:00:00Z","timestamp":1596499200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"National Research Foundation (NRF) of Korea funded by the Korean Government","award":["NRF-2019R1A2C1004045"],"award-info":[{"award-number":["NRF-2019R1A2C1004045"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Neuronal plasticity describes changes in structure, function, and connections of neurons. The hippocampus, in particular, has been shown to exhibit considerable plasticity regarding both physiological and morphological functions. Melatonin, a hormone released by the pineal gland, promotes cell survival and dendrite maturation of neurons in the newborn brain and protects against neurological disorders. In this study, we investigated the effect of exogenous melatonin on neuronal architecture and its possible mechanism in the hippocampus of adult male C57BL\/6 mice. Melatonin treatment significantly increased the total length and complexity of dendrites in the apical and basal\n                    <jats:italic>cornu ammonis<\/jats:italic>\n                    (CA) 1 and in the dentate gyrus in mouse hippocampi. Spine density in CA1 apical dendrites was increased, but no significant differences in other subregions were observed. In primary cultured hippocampal neurons, the length and arborization of neurites were significantly augmented by melatonin treatment. Additionally, western blot and immunohistochemical analyses in both\n                    <jats:italic>in vivo<\/jats:italic>\n                    and\n                    <jats:italic>in vitro<\/jats:italic>\n                    systems revealed significant increases in the level of cysteine\u2010rich protein 1 (crp\u20101) protein, which is known to be involved in dendritic branching in mouse hippocampal neurons after melatonin treatment. Our results suggest that exogenous melatonin leads to significant alterations of neuronal micromorphometry in the adult hippocampus, possibly via crp\u20101 signaling.\n                  <\/jats:p>","DOI":"10.1002\/jnr.24708","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T02:25:15Z","timestamp":1596594315000},"page":"2333-2348","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Melatonin alters neuronal architecture and increases cysteine\u2010rich protein 1 signaling in the male mouse hippocampus"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0998-3069","authenticated-orcid":false,"given":"Mary Jasmin","family":"Ang","sequence":"first","affiliation":[{"name":"Department of Veterinary Anatomy and Animal Behavior College of Veterinary Medicine and BK21 Plus Project Team Chonnam National University Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4689-5797","authenticated-orcid":false,"given":"Sohi","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Veterinary Anatomy and Animal Behavior College of Veterinary Medicine and BK21 Plus Project Team Chonnam National University Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2451-0374","authenticated-orcid":false,"given":"Changjong","family":"Moon","sequence":"additional","affiliation":[{"name":"Department of Veterinary Anatomy and Animal Behavior College of Veterinary Medicine and BK21 Plus Project Team Chonnam National University Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,4]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1369\/0022155413507453"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro-2014-0075"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2017.45"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14365"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14058"},{"issue":"7","key":"e_1_2_11_7_1","first-page":"892","article-title":"Regulation of the Mel 1a melatonin receptor mRNA and protein levels in the ovine pars tuberalis: Evidence for a cyclic adenosine 3',5'\u2010monophosphate\u2010independent Mel 1a receptor coupling and an autoregulatory mechanism of expression","volume":"10","author":"Barrett P.","year":"1996","journal-title":"Molecular Endocrinology"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2005.04.011"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2006.00408.x"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2005.00282.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12294"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0040844"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1534-5807(02)00396-9"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2014.00030"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-071013-014134"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyu075"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a029736"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jpi.12097"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2010.00775.x"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2011.00897.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2015.12.038"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-019-0477-7"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-079X.2011.00957.x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms16011907"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-008-0189-x"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.110.002832"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10605"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(02)03741-9"},{"issue":"3","key":"e_1_2_11_29_1","first-page":"237","article-title":"Molecular mechanisms of neuroplasticity: An expanding universe","volume":"82","author":"Gulyaeva N. 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