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No significant interaction effects of genotype PRS\u2010MDD with the environmental risk factor \u201cprenatal maternal depressive symptoms\u201d (genotype\u2010by\u2010environment interaction) nor significant interaction effects of genotype with prenatal maternal depressive symptoms and sex (genotype\u2010by\u2010environment\u2010by\u2010sex interaction) were found for infant dorsal striatal volumes. Our study showed that a higher PRS\u2010MDD irrespective of prenatal exposure to maternal depressive symptoms is associated with smaller bilateral caudate volumes, an indicator of greater susceptibility to major depressive disorder, in female compared to male infants. This sex\u2010specific polygenic effect might lay the ground for the higher prevalence of depression in women compared to men.<\/jats:p>","DOI":"10.1002\/jnr.24722","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T03:21:42Z","timestamp":1600312902000},"page":"2529-2540","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Sex\u2010specific association between infant caudate volumes and a polygenic risk score for major depressive disorder"],"prefix":"10.1002","volume":"98","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8580-1402","authenticated-orcid":false,"given":"Henriette","family":"Acosta","sequence":"first","affiliation":[{"name":"FinnBrain Birth Cohort Study Turku Brain and Mind Center Department of Clinical Medicine University of Turku Turku Finland"},{"name":"Department of Psychiatry and Psychotherapy Philipps University of Marburg Marburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katri","family":"Kantoj\u00e4rvi","sequence":"additional","affiliation":[{"name":"Finnish Institute for Health and Welfare Genomics and Biobank Unit Helsinki Finland"},{"name":"Department of Psychiatry and SleepWell Research Program Faculty of Medicine University of Helsinki and Helsinki University Central Hospital Helsinki Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jetro J.","family":"Tuulari","sequence":"additional","affiliation":[{"name":"FinnBrain Birth Cohort Study Turku Brain and Mind Center Department of Clinical Medicine University of Turku Turku Finland"},{"name":"Department of Psychiatry University of Turku and Turku University Hospital Turku Finland"},{"name":"Turku Collegium for Science and Medicine University of Turku Turku Finland"},{"name":"Department of Psychiatry University of Oxford Oxford UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John D.","family":"Lewis","sequence":"additional","affiliation":[{"name":"Montreal Neurological Institute McGill University Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niloofar","family":"Hashempour","sequence":"additional","affiliation":[{"name":"FinnBrain Birth Cohort Study Turku Brain and Mind Center Department of Clinical Medicine University of Turku Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noora M.","family":"Scheinin","sequence":"additional","affiliation":[{"name":"FinnBrain Birth Cohort Study Turku Brain and Mind Center Department of Clinical Medicine University of Turku Turku Finland"},{"name":"Department of Psychiatry University of Turku and Turku University Hospital Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satu J.","family":"Lehtola","sequence":"additional","affiliation":[{"name":"FinnBrain Birth Cohort Study Turku Brain and Mind Center Department of Clinical Medicine University of Turku Turku Finland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3402-7749","authenticated-orcid":false,"given":"Vladimir S.","family":"Fonov","sequence":"additional","affiliation":[{"name":"Montreal Neurological Institute McGill University Montreal QC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. 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