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Also, shift\u2010work is are suggested to be a risk factor for the development of mood disorders such as the burn out syndrome, anxiety, and depression. Experimental and clinical studies provide evidence that food intake restricted to the normal activity phase is a potent synchronizer for the circadian system and can prevent the detrimental health effects associated with circadian disruption. Here, we explored whether adult male Wistar rats exposed to an experimental model of shift\u2010work (W\u2010AL) developed depressive and\/or anxiety\u2010like behaviors and whether this was associated with neuroinflammation in brain areas involved with mood regulation. We also tested whether time\u2010restricted feeding (TRF) to the active phase could ameliorate circadian disruption and therefore would prevent depressive and anxiety\u2010like behaviors as well as neuroinflammation. In male Wistar rats, W\u2010AL induced depressive\u2010like behavior characterized by hypoactivity and anhedonia and induced increased anxiety\u2010like behavior in the open field test. This was associated with increased number of glial fibrillary acidic protein and IBA\u20101\u2010positive cells in the prefrontal cortex and basolateral amygdala. Moreover W\u2010AL caused morphological changes in the microglia in the CA3 area of the hippocampus indicating microglial activation. Importantly, TRF prevented behavioral changes and decreased neuroinflammation markers in the brain. Present results add up evidence about the importance that TRF in synchrony with the light\u2013dark cycle can prevent neuroinflammation leading to healthy mood states in spite of circadian disruptive conditions.<\/jats:p>","DOI":"10.1002\/jnr.24741","type":"journal-article","created":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T09:14:41Z","timestamp":1603185281000},"page":"604-620","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Time\u2010restricted feeding prevents depressive\u2010like and anxiety\u2010like behaviors in male rats exposed to an experimental model of shift\u2010work"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6048-7047","authenticated-orcid":false,"given":"Natal\u00ed N.","family":"Guerrero\u2010Vargas","sequence":"first","affiliation":[{"name":"Departamento de Anatom\u00eda Facultad de Medicina Universidad Nacional Aut\u00f3noma de M\u00e9xico Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4157-4380","authenticated-orcid":false,"given":"Carmen","family":"Z\u00e1rate\u2010Mozo","sequence":"additional","affiliation":[{"name":"Departamento de Anatom\u00eda Facultad de Medicina Universidad Nacional Aut\u00f3noma de M\u00e9xico Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2549-1518","authenticated-orcid":false,"given":"Mara A.","family":"Guzm\u00e1n\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda Facultad de Medicina Universidad Nacional Aut\u00f3noma de M\u00e9xico Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7960-1842","authenticated-orcid":false,"given":"Alfredo","family":"C\u00e1rdenas\u2010Rivera","sequence":"additional","affiliation":[{"name":"Centro de Investigaci\u00f3n en Bioingenier\u00eda Universidad de Ingenier\u00eda y Tecnolog\u00eda Lima Per\u00fa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2974-7875","authenticated-orcid":false,"given":"Carolina","family":"Escobar","sequence":"additional","affiliation":[{"name":"Departamento de Anatom\u00eda Facultad de Medicina Universidad Nacional Aut\u00f3noma de M\u00e9xico Ciudad de M\u00e9xico M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.22108"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748730411409715"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.06.001"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/brb3.1028"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2009.11.013"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1515308112"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-016-4214-0"},{"key":"e_1_2_11_9_1","doi-asserted-by":"crossref","first-page":"e12872","DOI":"10.1111\/jsr.12872","article-title":"Exploring the associations between shift work disorder, depression, anxiety and sick leave taken amongst nurses","volume":"29","author":"Booker L. 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