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Many studies have shown strong associations between oral disorders and systemic disorders, such as diabetes, arthritis, sepsis, aspiration pneumonia, arteriosclerosis, bacterial endocarditis, and other cardiovascular diseases. Similarly, numerous cross\u2010sectional studies showed that patients with dementia usually have poor oral conditions and tooth loss. These have long been considered as a result of difficulty with oral care due to impaired cognitive function, memory, and physical ability in patients with dementia. Indeed, even in patients with mild cognitive impairment, oral care becomes insufficient owing to decreases in spontaneity of grooming and finger dexterity. However, recent studies have shown that tooth loss and occlusal dysfunction may affect brain function and trigger the onset of dementia found in neurodegenerative diseases including Alzheimer's disease. In this review, we highlight the relationships among aging, oral dysfunction, and the development of dementia. Increasing evidence suggests that oral dysfunction is not only a result of dementia in the elderly people, but could also be a causative factor for the onset of dementia.<\/jats:p>","DOI":"10.1002\/jnr.24745","type":"journal-article","created":{"date-parts":[[2020,11,9]],"date-time":"2020-11-09T00:23:12Z","timestamp":1604881392000},"page":"518-528","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":126,"title":["Oral dysfunctions and cognitive impairment\/dementia"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8222-9225","authenticated-orcid":false,"given":"Tomohisa","family":"Nakamura","sequence":"first","affiliation":[{"name":"Department of Biochemistry Nagoya City University Graduate School of Medical Sciences Nagoya Japan"},{"name":"Maxillofacial Surgery Nagoya City University Graduate School of Medical Sciences Nagoya 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