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It has surprising transmissibility potential, since it could infect all ages, gender, and human sectors. It attacks respiratory, gastrointestinal, urinary, hepatic, and endovascular systems and can reach the peripheral nervous system (PNS) and central nervous system (CNS) through known and unknown mechanisms. The reports on the neurological manifestations and complications of the SARS\u2010CoV\u20102 infection are increasing exponentially. Herein, we enumerate seven candidate routes, which the mature or immature SARS\u2010CoV\u20102 components could use to reach the CNS and PNS, utilizing the within\u2010body cross talk between organs. The majority of SARS\u2010CoV\u20102\u2013infected patients suffer from some neurological manifestations (e.g., confusion, anosmia, and ageusia). It seems that although the mature virus did not reach the CNS or PNS of the majority of patients, its unassembled components and\/or the accompanying immune\u2010mediated responses may be responsible for the observed neurological symptoms. The viral particles and\/or its components\u00a0have been specifically documented in endothelial cells of lung, kidney, skin, and CNS. This means that the blood\u2013endothelial barrier may be considered as the main route for SARS\u2010CoV\u20102 entry into the nervous system, with the barrier disruption being more logical than barrier permeability, as evidenced by postmortem analyses.<\/jats:p>","DOI":"10.1002\/jnr.24752","type":"journal-article","created":{"date-parts":[[2020,11,21]],"date-time":"2020-11-21T03:31:27Z","timestamp":1605929487000},"page":"750-777","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Severe acute respiratory syndrome coronavirus 2 infection reaches the human nervous system: How?"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4037-5857","authenticated-orcid":false,"given":"Vladimir N.","family":"Uversky","sequence":"first","affiliation":[{"name":"Biological Science Department Faculty of Science King Abdulaziz University Jeddah Saudi Arabia"},{"name":"Department of Molecular Medicine and USF Health Byrd Alzheimer's Research Institute, Morsani College of Medicine University of South Florida Tampa FL USA"},{"name":"Institute for Biological Instrumentation of the Russian Academy of Sciences Federal Research Center \u201cPushchino Scientific Center for Biological Research of the Russian Academy of Sciences\u201d Pushchino Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatma","family":"Elrashdy","sequence":"additional","affiliation":[{"name":"Department of Endemic Medicine and Hepatogastroenterology Kasr Alainy School of Medicine Cairo University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Aljadawi","sequence":"additional","affiliation":[{"name":"Biological Science Department Faculty of Science King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Moasfar","family":"Ali","sequence":"additional","affiliation":[{"name":"Interdisciplinary Biotechnology Unit Aligarh Muslim University Aligarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rizwan Hasan","family":"Khan","sequence":"additional","affiliation":[{"name":"Interdisciplinary Biotechnology Unit Aligarh Muslim University Aligarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8246-0075","authenticated-orcid":false,"given":"Elrashdy M.","family":"Redwan","sequence":"additional","affiliation":[{"name":"Biological Science Department Faculty of Science King Abdulaziz University Jeddah Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,20]]},"reference":[{"key":"e_1_2_22_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01312"},{"key":"e_1_2_22_3_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1469-7580.2002.00064.x"},{"key":"e_1_2_22_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20123108"},{"key":"e_1_2_22_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2015432"},{"key":"e_1_2_22_6_1","article-title":"Is Guillain\u2010Barr\u00e8 syndrome triggered by SARS\u2010CoV\u20102? 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