{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:11:57Z","timestamp":1772118717067,"version":"3.50.1"},"reference-count":62,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T00:00:00Z","timestamp":1611100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Rapid eye movement sleep behavior disorder (RBD) is a common condition found in more than 50% of the patients with Parkinson's disease (PD). Molecular imaging shows that PD with RBD (PD\u2010RBD+) have lower striatal dopamine transporter activity within the caudate and putamen relative to PD without RBD (PD\u2010RBD\u2212). However, the characterization of the extra\u2010striatal dopamine within the mesocortical and mesolimbic pathways remains unknown. We aim to elucidate this with PET imaging in 15 PD\u2010RBD+ and 15 PD\u2010RBD\u2212 patients, while having 15 age\u2010matched healthy controls (HC). Each participant underwent a single PET scan with [\n                    <jats:sup>11<\/jats:sup>\n                    C]FLB\u2010457 to detect the D2 receptor availability within the extra\u2010striatal regions of interest (ROI), including the prefrontal, temporal, and limbic areas. [\n                    <jats:sup>11<\/jats:sup>\n                    C]FLB\u2010457 retention was expressed as the nondisplaceable binding potential. Our results reveal that relative to HC, PD\u2010RBD+ and PD\u2010RBD\u2212 patients have lower levels of D2 receptor availability within the uncus parahippocampus, superior, lateral, and inferior temporal cortex. PD\u2010RBD+ showed steep decline in D2 receptors within the left uncus parahippocampus with increasing disease severity, but this was not observed for PD\u2010RBD\u2212 patients. Findings imply that extra\u2010striatal dopaminergic system may play a role in contributing to symptomatic progress in PD patients with RBD. However, validation with more advanced PD patients are needed.\n                  <\/jats:p>","DOI":"10.1002\/jnr.24779","type":"journal-article","created":{"date-parts":[[2021,1,20]],"date-time":"2021-01-20T08:38:52Z","timestamp":1611131932000},"page":"1177-1187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Extra\u2010striatal dopamine in Parkinson's disease with rapid eye movement sleep behavior disorder"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4059-2333","authenticated-orcid":false,"given":"Mikaeel","family":"Valli","sequence":"first","affiliation":[{"name":"Brain Health Imaging Centre Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health University of Toronto ON Canada"},{"name":"Krembil Research Institute University Health Network University of Toronto ON Canada"},{"name":"Institute of Medical Science University of Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Soo","family":"Cho","sequence":"additional","affiliation":[{"name":"Brain Health Imaging Centre Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health University of Toronto ON Canada"},{"name":"Krembil Research Institute University Health Network University of Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Masellis","sequence":"additional","affiliation":[{"name":"Institute of Medical Science University of Toronto ON Canada"},{"name":"Hurvitz Brain Sciences Program Sunnybrook Research Institute Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert","family":"Chen","sequence":"additional","affiliation":[{"name":"Krembil Research Institute University Health Network University of Toronto ON Canada"},{"name":"Institute of Medical Science University of Toronto ON Canada"},{"name":"Morton and Gloria Shulman Movement Disorder Unit &amp; E.J. Safra Parkinson Disease Program, Neurology Division Department of Medicine Toronto Western Hospital, UHN University of Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuko","family":"Koshimori","sequence":"additional","affiliation":[{"name":"Brain Health Imaging Centre Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health University of Toronto ON Canada"},{"name":"Music and Health Research Collaboratory (MaRC) Faculty of Music University of Toronto Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Diez\u2010Cirarda","sequence":"additional","affiliation":[{"name":"Brain Health Imaging Centre Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health University of Toronto ON Canada"},{"name":"Krembil Research Institute University Health Network University of Toronto ON Canada"},{"name":"Neurodegenerative Diseases Group Biocruces Bizkaia Health Research Institute Barakaldo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8399-7883","authenticated-orcid":false,"given":"Alexander","family":"Mihaescu","sequence":"additional","affiliation":[{"name":"Brain Health Imaging Centre Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health University of Toronto ON Canada"},{"name":"Krembil Research Institute University Health Network University of Toronto ON Canada"},{"name":"Institute of Medical Science University of Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leigh","family":"Christopher","sequence":"additional","affiliation":[{"name":"Brain Health Imaging Centre Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health University of Toronto ON Canada"},{"name":"Krembil Research Institute University Health Network University of Toronto ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio P.","family":"Strafella","sequence":"additional","affiliation":[{"name":"Brain Health Imaging Centre Campbell Family Mental Health Research Institute Centre for Addiction and Mental Health University of Toronto ON Canada"},{"name":"Krembil Research Institute University Health Network University of Toronto ON Canada"},{"name":"Institute of Medical Science University of Toronto ON Canada"},{"name":"Morton and Gloria Shulman Movement Disorder Unit &amp; E.J. 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