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There is an urgent need to develop new diagnostic tools so that patients can be accurately stratified at an early stage. As a common post\u2010translational modification, protein glycosylation plays a key role in physiological and pathological processes. The abnormal changes in glycosylation are associated with the altered biological pathways in NDs. The pathogenesis\u2010related proteins, like amyloid\u2010\u03b2 and microtubule\u2010associated protein tau, have altered glycosylation. Importantly, specific glycosylation changes in cerebrospinal fluid, blood and urine are valuable for revealing neurodegeneration in the early stages. This review describes the emerging biomarkers based on glycoproteomics in NDs, highlighting the potential applications of glycoprotein biomarkers in the early detection of diseases, monitoring of the disease progression, and measurement of the therapeutic responses. The mass spectrometry\u2010based strategies for characterizing glycoprotein biomarkers are also introduced.<\/jats:p>","DOI":"10.1002\/jnr.24805","type":"journal-article","created":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T04:44:30Z","timestamp":1614314670000},"page":"1308-1324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Glycoproteins as diagnostic and prognostic biomarkers for neurodegenerative diseases: A glycoproteomic approach"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8158-2879","authenticated-orcid":false,"given":"Ming\u2010ming","family":"Xu","sequence":"first","affiliation":[{"name":"Center for Clinical Mass Spectrometry College of Pharmaceutical Sciences Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mao\u2010tian","family":"Zhou","sequence":"additional","affiliation":[{"name":"DMPK, WuXi AppTec Co., Ltd Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu\u2010wei","family":"Li","sequence":"additional","affiliation":[{"name":"Nanjing Apollomics Biotech, Inc. 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