{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T15:50:39Z","timestamp":1787932239364,"version":"build-2784847793"},"reference-count":72,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T00:00:00Z","timestamp":1615248000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["R01NS086945"],"award-info":[{"award-number":["R01NS086945"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pericles.pericles-gcp.literatumonline.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Developmental brain injury describes a spectrum of neurological pathologies resulting from either antenatal or perinatal injury. This includes both cognitive and motor defects that affect patients for their entire lives. Developmental brain injury can be caused by a spectrum of conditions including stroke, perinatal hypoxia\u2010ischemia, and intracranial hemorrhage. Additional risk factors have been identified including very low birth weight, mechanical ventilation, and oxygen (O\n                    <jats:sub>2<\/jats:sub>\n                    ) supplementation. In fact, infants with bronchopulmonary dysplasia, an inflammatory disease associated with disrupted lung development, have been shown to have decreased cerebral white matter and decreased intracranial volumes. Thus, there appears to be a developmental link between the lung, O\n                    <jats:sub>2<\/jats:sub>\n                    , and the brain that leads to proper myelination. Here, we will discuss what is currently known about the link between O\n                    <jats:sub>2<\/jats:sub>\n                    and myelination and how scientists are exploring mechanisms through which supplemental O\n                    <jats:sub>2<\/jats:sub>\n                    and\/or lung injury can affect brain development. Consideration of a link between the diseased lung and developing brain will allow clinicians to fine tune their approaches in managing preterm lung disease in order to optimize brain health.\n                  <\/jats:p>","DOI":"10.1002\/jnr.24816","type":"journal-article","created":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T06:35:53Z","timestamp":1615271753000},"page":"2127-2137","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["How lung injury and therapeutic oxygen could alter white matter development"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3074-5922","authenticated-orcid":false,"given":"Robert W.","family":"Dettman","sequence":"first","affiliation":[{"name":"Perinatal Origins of Disease Stanley Manne Children's Research Institute  Chicago IL USA"},{"name":"Department of Pediatrics Northwestern University Feinberg School of Medicine  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0102-4157","authenticated-orcid":false,"given":"Maria L. V.","family":"Dizon","sequence":"additional","affiliation":[{"name":"Perinatal Origins of Disease Stanley Manne Children's Research Institute  Chicago IL USA"},{"name":"Department of Pediatrics Northwestern University Feinberg School of Medicine  Chicago IL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002531"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2015.00090"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469\u20108749.2010.03612.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0049023"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep43000"},{"issue":"3","key":"e_1_2_11_7_1","first-page":"301","article-title":"Motor development at term of very low birth weight infants with bronchopulmonary dysplasia","volume":"9","author":"Byrne P. 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