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Long non\u2010coding RNAs (lncRNAs) are an important class of ncRNAs involved in a variety of biological functions, including transcriptional regulation and post\u2010transcriptional modification of many targets, and likely contributed to the pathogenesis of HD. While a number of changes in lncRNAs expression have been observed in HD, little is currently known about their functions. Here, we discuss their possible mechanisms and molecular functions, with a particular focus on their roles in transcriptional regulation. These findings give us a better insight into HD pathogenesis and may provide new targets for the treatment of this neurodegenerative disease.<\/jats:p>","DOI":"10.1002\/jnr.24825","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T22:33:42Z","timestamp":1621895622000},"page":"2074-2090","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Dysregulation of long non\u2010coding RNAs and their mechanisms in Huntington's disease"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3256-392X","authenticated-orcid":false,"given":"Xiaoping","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Neurology Shengjing Hospital of China Medical University Shenyang P.R. 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