{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:12:50Z","timestamp":1772118770907,"version":"3.50.1"},"reference-count":58,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T00:00:00Z","timestamp":1623369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Repetitive behavioral phenotypes are a trait of several neuropsychiatric disorders, including obsessive\u2010compulsive disorder (OCD). Such behaviors are typified by complex interactions between cognitive and neurobiological processes which most likely contribute to the suboptimal treatment responses often observed. To this end, exploration of the adenosinergic system may be useful, since adenosine\u2010receptor modulation has previously shown promise to restore control over voluntary behavior and improve cognition in patients presenting with motor repetition. Here, we employed the deer mouse\n                    <jats:italic>(Peromyscus maniculatus bairdii)<\/jats:italic>\n                    model of compulsive\u2010like behavioral persistence, seeking to investigate possible associations between stereotypic motor behavior and cognitive flexibility as measured in the T\u2010maze continuous alternation task (T\u2010CAT). The effect of istradefylline, a selective adenosine A\n                    <jats:sub>2A<\/jats:sub>\n                    receptor antagonist at two doses (10 and 20\u00a0mg\u00a0kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u00a0day\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) on the expression of stereotypy and T\u2010CAT performance in high (H) and non\u2010(N) stereotypical animals, was investigated in comparison to a control intervention (six groups;\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a08 or 9 per group). No correlation between H behavior and T\u2010CAT performance was found. However, H but not N animals presented with istradefylline\u2010sensitive spontaneous alternation and stereotypy, in that istradefylline at both doses significantly improved the spontaneous alternation scores and attenuated the stereotypical expression of H animals. Thus, evidence is presented that anti\u2010adenosinergic drug action improves repetitive behavior and spontaneous alternation in stereotypical deer mice, putatively pointing to a shared psychobiological construct underlying naturalistic stereotypy and alterations in cognitive flexibility in deer mice.\n                  <\/jats:p>","DOI":"10.1002\/jnr.24867","type":"journal-article","created":{"date-parts":[[2021,6,11]],"date-time":"2021-06-11T15:04:05Z","timestamp":1623423845000},"page":"2706-2720","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Stereotypy and spontaneous alternation in deer mice and its response to anti\u2010adenosinergic intervention"],"prefix":"10.1002","volume":"99","author":[{"given":"Geoffrey","family":"de Brouwer","sequence":"first","affiliation":[{"name":"Center of Excellence for Pharmaceutical Sciences Department of Pharmacology Faculty of Health Sciences North\u2010West University Potchefstroom South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaco","family":"Engelbrecht","sequence":"additional","affiliation":[{"name":"Center of Excellence for Pharmaceutical Sciences Department of Pharmacology Faculty of Health Sciences North\u2010West University Potchefstroom South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel C.","family":"Mograbi","sequence":"additional","affiliation":[{"name":"Department of Psychology Pontif\u00edcia Universidade Cat\u00f3lica \u2013 Rio (PUC\u2010Rio) Rio de Janeiro Brazil"},{"name":"Institute of Psychiatry, Psychology &amp; Neuroscience King\u2019s College London London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lesetja","family":"Legoabe","sequence":"additional","affiliation":[{"name":"Center of Excellence for Pharmaceutical Sciences Department of Pharmacology Faculty of Health Sciences North\u2010West University Potchefstroom South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan F.","family":"Steyn","sequence":"additional","affiliation":[{"name":"Center of Excellence for Pharmaceutical Sciences Department of Pharmacology Faculty of Health Sciences North\u2010West University Potchefstroom South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De Wet","family":"Wolmarans","sequence":"additional","affiliation":[{"name":"Center of Excellence for Pharmaceutical Sciences Department of Pharmacology Faculty of Health Sciences North\u2010West University Potchefstroom South Africa"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,6,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2018.09.003"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-clinpsy-032813-153713"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867325666171222163645"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.48"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2005.11.003"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300630"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2010.11.008"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0963721418787475"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.comppsych.2017.04.002"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130000674"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-801022-8.00012-X"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-020-09694-2"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocrd.2018.04.001"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2011.07719.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2020.112794"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/FBP.0000000000000536"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2006.2"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2005.04.003"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.16.7238"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mppsy.2007.04.001"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-5949.2009.00126.x"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2007.12.009"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2016.07.030"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.applanim.2005.08.006"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2007.08.032"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656560903446948"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpr.2009.09.005"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.11.003"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2013.12.026"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2013.795541"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-0102(02)00027-5"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2007.02.023"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2017.10.014"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2019.116070"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.parkreldis.2011.09.023"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.61.7.720"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jad.2015.05.013"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/ijnp\/pyv017"},{"issue":"1","key":"e_1_2_11_41_1","first-page":"81","article-title":"Neurocognitive endophenotypes of impulsivity and compulsivity: Towards dimensional psychiatry","volume":"16","author":"Robbins T. 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