{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:56:52Z","timestamp":1783508212403,"version":"3.55.0"},"reference-count":53,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T00:00:00Z","timestamp":1624579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS051402"],"award-info":[{"award-number":["NS051402"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS043285"],"award-info":[{"award-number":["NS043285"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS063141"],"award-info":[{"award-number":["NS063141"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS081936"],"award-info":[{"award-number":["NS081936"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS100088"],"award-info":[{"award-number":["NS100088"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["NS114972"],"award-info":[{"award-number":["NS114972"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pericles.pericles-gcp.literatumonline.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    All placental abruptions begin as partial abruptions, which sometimes manifest as fetal bradycardia. The progression from partial to total abruption was mimicked by a new rabbit model of placental insufficiency, and we compared it, with sufficient statistical power, with the previous model mimicking total placental abruption. The previous model uses total uterine ischemia at E22 or E25 (70% or 79% term, respectively), in pregnant New Zealand white rabbits for 40\u00a0min (Full H\u2010I). The new model, Partial+Full H\u2010I, added a 30\u2010min partial ischemia before the 40\u2010min total ischemia. Fetuses were delivered either at E31.5 (full term) vaginally for neurobehavior testing, or by C\u2010section at E25 for\n                    <jats:italic>ex vivo<\/jats:italic>\n                    brain cell viability evaluation. The onset of fetal bradycardia was within the first 2\u00a0min of either H\u2010I protocol. There was no difference between Full H\u2010I (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0442 for E22, 312 for E25) and Partial+Full H\u2010I (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a0154 and 80) groups in death or severely affected kits at E22 (76% vs. 79%) or at E25 (66% vs. 64%), or normal kits at E22 or E25, or any of the individual newborn neurobehavioral tests at any age. No sex differences were found. Partial+Full H\u2010I (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a06) showed less cell viability than Full H\u2010I (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a08) at 72\u2010hr\n                    <jats:italic>ex vivo<\/jats:italic>\n                    in the brain regions studied. Partial+Full H\u2010I insult produced similar cerebral palsy phenotype as our previous Full H\u2010I model in a sufficiently powered study and may be more suitable for testing of potential neuroprotectants.\n                  <\/jats:p>","DOI":"10.1002\/jnr.24901","type":"journal-article","created":{"date-parts":[[2021,6,25]],"date-time":"2021-06-25T20:49:22Z","timestamp":1624654162000},"page":"2138-2153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":40,"title":["Mimicking partial to total placental insufficiency in a rabbit model of cerebral palsy"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1912-229X","authenticated-orcid":false,"given":"Zhongjie","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Pediatrics Wayne State University  Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kehuan","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Wayne State University  Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanket","family":"Jani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Children\u2019s Hospital of Michigan Central Michigan University  Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"February","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Children\u2019s Hospital of Michigan Central Michigan University  Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nithi","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Children\u2019s Hospital of Michigan Central Michigan University  Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neha","family":"Venkatesh","sequence":"additional","affiliation":[{"name":"Wayne State University  Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadiya","family":"Sharif","sequence":"additional","affiliation":[{"name":"Wayne State University  Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidhartha","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Wayne State University  Detroit MI USA"},{"name":"Department of Pediatrics Children\u2019s Hospital of Michigan Central Michigan University  Detroit MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.17.1646"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2011.04.021"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450\u2010199711000\u201000021"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00233.2019"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.2002.tb00296.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.0000251445.94697.64"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2012.65"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-07-j0004.2001"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2816\u201003.2004"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000374107"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.112.653857"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21095"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600333"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.24115"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5986\u201011.2012"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2012.07.006"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2005.06.033"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035\u2010019\u20101548\u20108"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.107.510883"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.05.013"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0082200"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.82"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000241043"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0148122"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21555"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471\u20100528.2003.02088.x"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1093\/ilar\/ily021"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1177\/8756479308317006"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16207-7"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11325\u2010009\u20100307\u2010x"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1203\/PDR.0b013e3181a9ef34"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/wnp.0000000000000186"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301\u20102115(02)00219\u20101"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u20102393\u201013\u2010156"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23\u201008\u201003308.2003"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201045959\u20106"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1258\/002367783780959411"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.06.090"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1203\/pdr.0b013e318053664c"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-16082-1_13"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1159\/000499960"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1095\u20106433(99)00057\u20104"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.10.042"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clp.2013.10.006"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/08830738050200120801"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450\u2010199603000\u201000019"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2013.236"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2015\u20102872"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23256"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.21738"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00814"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.110.6.1220"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1159\/000327244"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.24901","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jnr.24901","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.24901","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T06:26:06Z","timestamp":1701239166000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.24901"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,25]]},"references-count":53,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1002\/jnr.24901"],"URL":"https:\/\/doi.org\/10.1002\/jnr.24901","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JNR.24901\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.24901\/v3\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.24901\/v3\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.24901\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.24901\/v4\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.24901\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.24901\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.24901\/v1\/decision1","asserted-by":"object"}]},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,25]]},"assertion":[{"value":"2021-01-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}