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The developmental mechanisms behind the formation of autonomic neurons and chromaffin cells are not fully understood. Using genetic tracing, we discovered that a significant proportion of sympathetic neurons in zebrafish originates from Schwann cell precursors (SCPs) during a defined period of embryonic development. Moreover, SCPs give rise to the main portion of the chromaffin cells, as well as to a significant proportion of enteric and other autonomic neurons associated with internal organs. The conversion of SCPs into neuronal and chromaffin cells is ErbB receptor dependent, as the pharmacological inhibition of the ErbB pathway effectively perturbed this transition. Finally, using genetic ablations, we revealed that SCPs producing neurons and chromaffin cells migrate along spinal motor axons to reach appropriate target locations. This study reveals the evolutionary conservation of SCP\u2010to\u2010neuron and SCP\u2010to\u2010chromaffin cell transitions over significant growth periods in fish and highlights relevant cellular\u2010genetic mechanisms. Based on this, we anticipate that multipotent SCPs might be present in postnatal vertebrate tissues, retaining the capacity to regenerate autonomic neurons and chromaffin cells.<\/jats:p>","DOI":"10.1002\/jnr.24909","type":"journal-article","created":{"date-parts":[[2021,6,28]],"date-time":"2021-06-28T20:57:53Z","timestamp":1624913873000},"page":"2540-2557","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Schwann cell precursors generate sympathoadrenal system during zebrafish development"],"prefix":"10.1002","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4399-9737","authenticated-orcid":false,"given":"Dmitrii","family":"Kamenev","sequence":"first","affiliation":[{"name":"Department of Neuroscience Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazunori","family":"Sunadome","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maxim","family":"Shirokov","sequence":"additional","affiliation":[{"name":"National Scientific Center of Marine Biology Far Eastern Branch Russian Academy of Sciences Vladivostok Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrey S.","family":"Chagin","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Karolinska Institutet Stockholm Sweden"},{"name":"Institute for Regenerative Medicine Sechenov University Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3819-5136","authenticated-orcid":false,"given":"Ajeet","family":"Singh","sequence":"additional","affiliation":[{"name":"Max\u2010Planck\u2010Institut f\u00fcr Entwicklungsbiologie T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Irion","sequence":"additional","affiliation":[{"name":"Max\u2010Planck\u2010Institut f\u00fcr Entwicklungsbiologie T\u00fcbingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor","family":"Adameyko","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology Karolinska Institutet Stockholm Sweden"},{"name":"Center for Brain Research Medical University Vienna Vienna Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Fried","sequence":"additional","affiliation":[{"name":"Department of Neuroscience Karolinska Institutet Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8100-7367","authenticated-orcid":false,"given":"Vyacheslav","family":"Dyachuk","sequence":"additional","affiliation":[{"name":"National Scientific Center of Marine Biology Far Eastern Branch Russian Academy of Sciences Vladivostok Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.07.049"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.12.12.1825"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1002044"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.10.6987"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.02668"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-017-2693-x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.087007"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e318260f20b"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1253281"},{"key":"e_1_2_11_11_1","article-title":"De novo enteric neurogenesis in post\u2010embryonic zebrafish from Schwann cell precursors rather than resident cell types","volume":"147","author":"El\u2010Nachef W. 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