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The purpose of this study was to investigate altered patterns of static and dynamic functional network connectivity (sFNC and dFNC) in TLE with different durations of disease. In this study, 19 TLE patients with a disease duration of \u22645\u00a0years (TLE\u2010SD), 24 TLE patients with a disease duration of &gt;5\u00a0years (TLE\u2010LD), and 21 healthy controls (HCs) underwent resting\u2010state functional magnetic resonance imaging and attention network test. We used group independent component analysis to determine the target resting\u2010state networks. Sliding window correlation and\n                    <jats:italic>k<\/jats:italic>\n                    \u2010means clustering analysis methods were used to obtain different dFNC states, temporal properties, and temporal variability. We then compared sFNC and dFNC between groups and found that compared with HCs, TLE\u2010SD patients had increased sFNC between the dorsal attention network and sensorimotor network\/visual network (VN), but decreased sFNC between the inferior\u2013posterior default mode network and VN. In the strongly connected dFNC state, TLE\u2010SD patients spent more time, had greater mean dwell time, and showed greater inconsistent abnormal network connectivity. There was a significant negative correlation between the temporal variability of auditory network\u2010 left fronto\u2010parietal network connectivity and orienting effect. No significant differences in sFNC and dFNC were detected between TLE\u2010LD and HC groups. These findings suggest that the damage and functional brain network abnormalities gradually occur in TLE patients after the onset of epilepsy, which might lead to functional network reorganization and compensatory remodeling as the disease progresses.\n                  <\/jats:p>","DOI":"10.1002\/jnr.24915","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T09:13:23Z","timestamp":1626426803000},"page":"2688-2705","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Altered static and dynamic functional network connectivity in temporal lobe epilepsy with different disease duration and their relationships with attention"],"prefix":"10.1002","volume":"99","author":[{"given":"Xiulin","family":"Liang","sequence":"first","affiliation":[{"name":"Department of Neurology the First Affiliated Hospital of Guangxi Medical University Nanning 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