{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:06:29Z","timestamp":1787061989385,"version":"build-2736575974"},"reference-count":56,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T00:00:00Z","timestamp":1631577600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102019R1A2C2085462"],"award-info":[{"award-number":["NRF\u20102019R1A2C2085462"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102018R1D1A1B07048959"],"award-info":[{"award-number":["NRF\u20102018R1D1A1B07048959"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The pons is one of the earliest affected regions in patients with synucleinopathies. We aimed to investigate the diagnostic value of measuring pontine damage using diffusion tensor imaging (DTI) in these patients. We enrolled 49 patients with Parkinson's disease (PD), 16 patients with idiopathic rapid eye movement sleep behavior disorder (iRBD), 23 patients with multiple system atrophy (MSA), and 39 healthy controls in this study. All the participants underwent high\u2010resolution T1\u2010weighted imaging and DTI. Mean diffusivity (MD) and fraction anisotropy (FA) values in the pons were calculated to characterize structural damage. The discriminatory power of pontine MD and FA values to differentiate patients with synucleinopathies from healthy controls was examined using receiver operating characteristics (ROC) analyses. Compared to healthy controls, patients with PD, iRBD, and MSA had increased MD values and decreased FA values in the pons, although no correlation was observed between these DTI measures and disease severity. The ROC analyses showed that MD values in the pons had a fair discriminatory power to differentiate healthy controls from patients with PD (area under the curve [AUC], 0.813), iRBD (AUC, 0.779), and MSA (AUC, 0.951). The AUC for pontine FA values was smaller than that for pontine MD values when differentiating healthy controls from patients with PD (AUC, 0.713;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.054) and iRBD (AUC, 0.686;\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a00.045). Our results suggest that MD values in the pons may be a useful marker of brain stem neurodegeneration in patients with synucleinopathies.\n                  <\/jats:p>","DOI":"10.1002\/jnr.24926","type":"journal-article","created":{"date-parts":[[2021,9,14]],"date-time":"2021-09-14T12:18:29Z","timestamp":1631621909000},"page":"2922-2931","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Diffusion tensor imaging\u2010based pontine damage as a degeneration marker in synucleinopathy"],"prefix":"10.1002","volume":"99","author":[{"given":"Seok Jong","family":"Chung","sequence":"first","affiliation":[{"name":"Department of Neurology Yonsei University College of Medicine  Seoul South Korea"},{"name":"Department of Neurology Yongin Severance Hospital Yonsei University Health System  Yongin South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyoo Ho","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Neurology Yonsei University College of Medicine  Seoul South Korea"},{"name":"Department of Neurology Seoul Hospital Ewha Womans University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang Hyun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han Soo","family":"Yoo","sequence":"additional","affiliation":[{"name":"Department of Neurology Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"KyoungWon","family":"Baik","sequence":"additional","affiliation":[{"name":"Department of Neurology Yonsei University College of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin 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