{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:09:32Z","timestamp":1791331772469,"version":"4.3.1"},"reference-count":67,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T00:00:00Z","timestamp":1631404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002551","name":"Seoul National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002551","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008783","name":"National Research Council of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008783","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Axons in the adult mammalian central nervous system fail to regenerate after injury. By contrast, spontaneous axon regeneration occurs in the peripheral nervous system (PNS) due to a supportive PNS environment and an increase in the intrinsic growth potential induced by injury via cooperative activation of multifaceted biological pathways. This study compared axon regeneration and injury responses in C57BL\/6 male and female mice after sciatic nerve crush (SNC) injury. The extent of axon regeneration\n                    <jats:italic>in vivo<\/jats:italic>\n                    was indistinguishable in male and female mice when observed at 3\u00a0days after SNC injury, and primary dorsal root ganglion (DRG) neurons from injured, male and female mice extended axons to a similar length. Moreover, the induction of selected regeneration\u2010associated genes (RAGs), such as\n                    <jats:italic>Atf3<\/jats:italic>\n                    ,\n                    <jats:italic>Sprr1a<\/jats:italic>\n                    ,\n                    <jats:italic>Gap43<\/jats:italic>\n                    ,\n                    <jats:italic>Sox11<\/jats:italic>\n                    ,\n                    <jats:italic>Jun<\/jats:italic>\n                    ,\n                    <jats:italic>Gadd45a<\/jats:italic>\n                    , and\n                    <jats:italic>Smad1<\/jats:italic>\n                    were comparable in male and female DRGs when assessed by quantitative real\u2010time reverse transcription polymerase chain reaction. Furthermore, the RNA\u2010seq analysis of male and female DRGs revealed that differentially expressed genes (DEGs) in SNC groups compared to sham\u2010operated groups included many common genes associated with neurite outgrowth. However, we also found that a large number of genes in the DEGs were sex dependent, implicating the involvement of distinct gene regulatory network in the two sexes following peripheral nerve injury. In conclusion, we found that male and female mice mounted a comparable axon regeneration response and many RAGs were commonly induced in response to SNC. However, given that many DEGs were sex\u2010dependently expressed, future studies are needed to investigate whether they contribute to peripheral axon regeneration, and if so, to what extent.\n                  <\/jats:p>","DOI":"10.1002\/jnr.24955","type":"journal-article","created":{"date-parts":[[2021,9,12]],"date-time":"2021-09-12T19:20:37Z","timestamp":1631474437000},"page":"2874-2887","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Comparing axon regeneration in male and female mice after peripheral nerve injury"],"prefix":"10.1002","volume":"99","author":[{"given":"Eun\u2010Hae","family":"Jang","sequence":"first","affiliation":[{"name":"Laboratory of Neuroscience Research Institute for Veterinary Science, College of Veterinary Medicine Seoul National University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun\u2010Hee","family":"Bae","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroscience Research Institute for Veterinary Science, College of Veterinary Medicine Seoul National University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5884-0286","authenticated-orcid":false,"given":"Eun Mo","family":"Yang","sequence":"additional","affiliation":[{"name":"Laboratory of Neuroscience Research Institute for Veterinary Science, College of Veterinary Medicine Seoul National University Seoul South Korea"},{"name":"BK21 Four Future Veterinary Medicine Leading Education &amp; 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