{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:10:14Z","timestamp":1772118614985,"version":"3.50.1"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T00:00:00Z","timestamp":1637798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 EY025789"],"award-info":[{"award-number":["R01 EY025789"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Glaucoma is one of the leading causes of irreversible blindness and can result from abnormalities in anterior segment structures required for aqueous humor outflow, including the trabecular meshwork (TM) and Schlemm's canal (SC). Transcription factors such as AP\u20102\u03b2 play critical roles in anterior segment development. Here, we show that the\n                    <jats:italic>Mgp\u2010<\/jats:italic>\n                    Cre knock\u2010in (\n                    <jats:italic>Mgp<\/jats:italic>\n                    \u2010Cre.KI) mouse can be used to target the embryonic periocular mesenchyme giving rise to the TM and SC. Fate mapping of male and female mice indicates that AP\u20102\u03b2 loss causes a decrease in iridocorneal angle cells derived from\n                    <jats:italic>Mgp<\/jats:italic>\n                    \u2010Cre.KI\u2010expressing populations compared to controls. Moreover, histological analyses revealed peripheral iridocorneal adhesions in AP\u20102\u03b2 mutants that were accompanied by a decrease in expression of TM and SC markers, as observed using immunohistochemistry. In addition, rebound tonometry showed significantly higher intraocular pressure (IOP) that was correlated with a progressive significant loss of retinal ganglion cells, reduced retinal thickness, and reduced retinal function, as measured using an electroretinogram, in AP\u20102\u03b2 mutants compared with controls, reflecting pathology described in late\u2010stage glaucoma patients. Importantly, elevated IOP in AP\u20102\u03b2 mutants was significantly reduced by treatment with latanoprost, a prostaglandin analog that increases unconventional outflow. These findings demonstrate that AP\u20102\u03b2 is critical for TM and SC development, and that these mutant mice can serve as a model for understanding and treating progressive human primary angle\u2010closure glaucoma.\n                  <\/jats:p>","DOI":"10.1002\/jnr.24982","type":"journal-article","created":{"date-parts":[[2021,11,26]],"date-time":"2021-11-26T05:54:03Z","timestamp":1637906043000},"page":"638-652","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Deletion of transcription factor AP\u20102\u03b2 from the developing murine trabecular meshwork region leads to progressive glaucomatous changes"],"prefix":"10.1002","volume":"100","author":[{"given":"Aftab","family":"Taiyab","sequence":"first","affiliation":[{"name":"Department of Pathology and Molecular Medicine McMaster University  Hamilton ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Akula","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine McMaster University  Hamilton ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Japnit","family":"Dham","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine McMaster University  Hamilton ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula","family":"Deschamps","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine McMaster University  Hamilton ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heather","family":"Sheardown","sequence":"additional","affiliation":[{"name":"Department of Chemical Engineering McMaster University  Hamilton ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Trevor","family":"Williams","sequence":"additional","affiliation":[{"name":"Department of Craniofacial Biology University of Colorado  Aurora CO USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa","family":"Borr\u00e1s","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of North Carolina School of Medicine  Chapel Hill NC USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4293-9131","authenticated-orcid":false,"given":"Judith A.","family":"West\u2010Mays","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Medicine McMaster University  Hamilton ON Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,25]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","first-page":"146","article-title":"Reduction of intraocular pressure in mouse eyes treated with latanoprost","volume":"43","author":"Aihara M.","year":"2002","journal-title":"Investigative Ophthalmology & Visual Science"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24074"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2020.108042"},{"key":"e_1_2_11_5_1","first-page":"1967","article-title":"Latanoprost in the treatment of glaucoma","volume":"8","author":"Alm A.","year":"2014","journal-title":"Clinical Ophthalmology"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-22992"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11752-6"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.23762"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00687-07"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq060"},{"issue":"6","key":"e_1_2_11_11_1","first-page":"1258","article-title":"Retinal morphology and ERG response in the DBA\/2NNia mouse model of angle\u2010closure glaucoma","volume":"42","author":"Bayer A. 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