{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:10:14Z","timestamp":1772118614925,"version":"3.50.1"},"reference-count":66,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T00:00:00Z","timestamp":1640044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18H03379"],"award-info":[{"award-number":["18H03379"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Thyroid hormones play an important role in the central and peripheral nervous system functions. Approximately 50% of adult\u2010onset hypothyroid patients have sensory symptoms including pain, possibly caused by peripheral neuropathy. However, the mechanism causing the pain has not been clarified. We generated an adult\u2010onset hypothyroid model animal by administering 50\u00a0ppm propylthiouracil (PTU) for 5\u00a0weeks to male mice. Female mice were not tested in this study. Mechanical hypersensitivity, determined by the von Frey hair test, was observed during the PTU exposure and recovered after the exposure termination. The sciatic nerve compound action potential was also analyzed. Under single\u2010pulse stimulation, no significant change in the threshold and conduction velocity was observed in the PTU\u2010administered group. On the other hand, under train\u2010pulse stimulation, the latency delay in the A\u03b4\u2010fiber component was less in the PTU\u2010administered group in Week 4 of PTU exposure, indicating relative hyperexcitability. Fluticasone, which is the anti\u2010inflammatory agent with an ability to activate the voltage\u2010gated potassium channel subfamily A (Kv1), restored the decrease in the latency change ratio by PTU exposure under the train\u2010pulse stimulation supporting our hypothesis that Kv1 may be involved in the conductivity change. Kv1.1 protein level decreased significantly in the sciatic nerve of the PTU\u2010administered group. These results indicate that adult\u2010onset hypothyroidism causes mechanical hypersensitivity owing to hyperexcitability of the peripheral nerve and that reduction of Kv1.1 level may be involved in such alteration.<\/jats:p>","DOI":"10.1002\/jnr.25001","type":"journal-article","created":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T21:00:21Z","timestamp":1640120421000},"page":"506-521","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Adult\u2010onset hypothyroidism causes mechanical hypersensitivity due to peripheral nerve hyperexcitability based on voltage\u2010gated potassium channel downregulation in male mice"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9297-8441","authenticated-orcid":false,"given":"Machiko","family":"Suda","sequence":"first","affiliation":[{"name":"Department of Integrative Physiology Gunma University Graduate School of Medicine  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2730-3402","authenticated-orcid":false,"given":"Yusuke","family":"Takatsuru","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Health Science Toyo University  Ora\u2010gun Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5076-2041","authenticated-orcid":false,"given":"Izuki","family":"Amano","sequence":"additional","affiliation":[{"name":"Department of Integrative Physiology Gunma University Graduate School of Medicine  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8731-3311","authenticated-orcid":false,"given":"Shogo","family":"Haraguchi","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Showa University School of Medicine  Shinagawa\u2010ku Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2247-9740","authenticated-orcid":false,"given":"Noriyuki","family":"Koibuchi","sequence":"additional","affiliation":[{"name":"Department of Integrative Physiology Gunma University Graduate School of Medicine  Maebashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2017-03125"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0034"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2003.10.033"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.52.12.1420"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(01)00568-1"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1985.sp015769"},{"issue":"3","key":"e_1_2_12_8_1","first-page":"121","article-title":"Response of single alpha motoneurons to high\u2010frequency pulse trains. 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