{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T05:33:12Z","timestamp":1778131992370,"version":"3.51.4"},"reference-count":60,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T00:00:00Z","timestamp":1640736000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    There is increasing evidence for the important role of gut microbiota (GMB) in the development and progression of neurologic pathologies. Some studies have shown that modifying the microbiome profile can confer benefits to patients. Mild traumatic brain injury (mTBI) is a common occurrence in the general population. Although most patients recover, in a minority, disabling symptoms can persist for several months. We carried out a review of the literature to assess the effect of mTBI on GMB and to determine whether alleviating dysbiosis can improve clinical outcomes in mTBI patients. We performed searches in Medline\/PubMed and Embase using the keywords \u201cMTBI\u201d AND \u201cmicrobiome\u201d OR \u201cmicrobiota\u201d. Additional articles were identified by manual searches and using the Google search engine. In animal models, a clear perturbation of GMB was reported following TBI and probiotic supplementation (\n                    <jats:italic>Lactobacillus acidophilus<\/jats:italic>\n                    or\n                    <jats:italic>Clostridium butyricum<\/jats:italic>\n                    ) improved neurologic function. There were no studies on changes in GMB after mTBI in humans; however, pre\u2010 or probiotic supplementation reduced the infection rate in patients with severe TBI and shortened the time spent in the intensive care unit without conferring any neurologic benefits. Thus, although the findings from animal models are promising, clinical studies are needed to determine whether therapeutic strategies that restore gut microbiome profile can improve long\u2010term outcomes of patients with mTBI.\n                  <\/jats:p>","DOI":"10.1002\/jnr.25004","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T05:54:59Z","timestamp":1640757299000},"page":"827-834","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Relationship between mild traumatic brain injury and the gut microbiome: A scoping review"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8389-8167","authenticated-orcid":false,"given":"Nozar","family":"Aghakhani","sequence":"first","affiliation":[{"name":"Department of Neurosurgery Center for Evaluation and Multidisciplinary Care of the Mild Traumatic Brain Injury Bic\u00eatre University Hospital  Le 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