{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:12:25Z","timestamp":1772118745423,"version":"3.50.1"},"reference-count":76,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T00:00:00Z","timestamp":1645488000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004595","name":"Universiti Sains Malaysia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Working memory (WM) encompasses crucial cognitive processes or abilities to retain and manipulate temporary information for immediate execution of complex cognitive tasks in daily functioning such as reasoning and decision\u2010making. The WM of individuals sustaining traumatic brain injury (TBI) was commonly compromised, especially in the domain of WM. The current study investigated the brain responses of WM in a group of participants with mild\u2013moderate TBI compared to their healthy counterparts employing functional magnetic resonance imaging. All consented participants (healthy:\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a026 and TBI:\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a015) performed two variations of the n\u2010back WM task with four load conditions (0\u2010, 1\u2010, 2\u2010, and 3\u2010back). The respective within\u2010group effects showed a right hemisphere\u2010dominance activation and slower reaction in performance for the TBI group. Random\u2010effects analysis revealed activation difference between the two groups in the right occipital lobe in the guided n\u2010back with cues, and in the bilateral occipital lobe, superior parietal region, and cingulate cortices in the n\u2010back without cues. The left middle frontal gyrus was implicated in the load\u2010dependent processing of WM in both groups. Further group analysis identified that the notable activation changes in the frontal gyri and anterior cingulate cortex are according to low and high loads. Though relatively smaller in scale, this study was eminent as it clarified the neural alterations in WM in the mild\u2013moderate TBI group compared to healthy controls. It confirmed the robustness of the phenomenon in TBI with the reproducibility of the results in a heterogeneous non\u2010Western sample.\n                  <\/jats:p>","DOI":"10.1002\/jnr.25023","type":"journal-article","created":{"date-parts":[[2022,2,23]],"date-time":"2022-02-23T03:03:06Z","timestamp":1645585386000},"page":"915-932","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Neural alterations in working memory of mild\u2010moderate TBI: An fMRI study in Malaysia"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5854-6669","authenticated-orcid":false,"given":"Wen Jia","family":"Chai","sequence":"first","affiliation":[{"name":"Department of Neurosciences, School of Medical Sciences Universiti Sains Malaysia  Kota Bharu Malaysia"},{"name":"Brain and Behaviour Cluster, School of Medical Sciences Universiti Sains Malaysia  Kota Bharu 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