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Here, we investigated whether anosmia was associated with gray matter volume alterations at a network level, and whether these alterations were related to the olfactory\u2010specific quality of life (QOL) and depressive symptoms. Structural brain magnetic resonance imaging was acquired in 22 individuals with postinfectious or idiopathic anosmia (the anosmia group) and 30 age\u2010 and sex\u2010matched controls (the control group). Using independent component analysis on the gray matter volumes, we identified 10 morphometric networks. The gray matter volumes of these networks were compared between the two groups. Olfactory\u2010specific QOL and depressive symptoms were assessed by self\u2010report questionnaires and clinician\u2010administered interviews, respectively. The anosmia group showed lower gray matter volumes in the hippocampus\u2013amygdala and the precuneus networks, relative to the control group. Lower gray matter volumes in the hippocampus\u2013amygdala network were also linearly associated with lower olfactory\u2010specific QOL and higher depressive symptom scores. These findings suggest a close relationship between anosmia and gray matter volume alterations in the emotional brain networks, albeit without determined causal relations.<\/jats:p>","DOI":"10.1002\/jnr.25037","type":"journal-article","created":{"date-parts":[[2022,3,3]],"date-time":"2022-03-03T19:34:36Z","timestamp":1646336076000},"page":"1321-1330","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Gray matter volume reduction in the emotional brain networks in adults with anosmia"],"prefix":"10.1002","volume":"100","author":[{"given":"Suji","family":"Lee","sequence":"first","affiliation":[{"name":"Ewha Brain Institute Ewha W. University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jungyoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Ewha Brain Institute Ewha W. University  Seoul South Korea"},{"name":"Department of Brain and Cognitive Sciences Ewha W. University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bong Jik","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Chungnam National University College of Medicine, Chungnam National University Sejong Hospital  Sejong South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rye Young","family":"Kim","sequence":"additional","affiliation":[{"name":"Ewha Brain Institute Ewha W. University  Seoul South Korea"},{"name":"Graduate School of Pharmaceutical Sciences Ewha W. 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