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In this study, we established the ICH model in male mice and found that IL\u201018 expression including protein and mRNA levels was significantly increased in brain tissues after ICH. Meanwhile, exogenous IL\u201018 exacerbated cerebral hematoma and neurological deficits following ICH. In the IL\u201018 knockout group, the size of hematoma and neurological functions after ICH was decreased compared with the wild\u2010type group, suggesting the critical role of IL\u201018 on the modulation of brain injury after ICH. Importantly, exogenous IL\u201018 increased microglial activation in brain tissues after ICH. Furthermore, IL\u201018 knockout resulted in the reduction of activated microglia after ICH. These results indicated that IL\u201018 may regulate the inflammatory response after ICH through the activation of microglia. Thus, IL\u201018 is expected to be a promising therapeutic target for secondary brain injury after ICH.<\/jats:p>","DOI":"10.1002\/jnr.25044","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T15:09:17Z","timestamp":1647961757000},"page":"1359-1369","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Interleukin\u201018 mediated inflammatory brain injury after intracerebral hemorrhage in male mice"],"prefix":"10.1002","volume":"100","author":[{"given":"Hao","family":"Li","sequence":"first","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingluan","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yin","family":"Yin","sequence":"additional","affiliation":[{"name":"Laboratory Animal Center Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshan","family":"Diao","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ximeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Orthopedics Xuzhou Medical University Affiliated Hospital  Xuzhou City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhigang","family":"Miao","sequence":"additional","affiliation":[{"name":"Institute of Neuroscience Soochow University  Suzhou City China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7896-9485","authenticated-orcid":false,"given":"Yi","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Neurology The First Affiliated Hospital of Soochow University  Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,22]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-7-9"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.4274\/balkanmedj.2017.0323"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jcbfm.9600026"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102937"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.119.027134"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1996.0178"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2018.07.024"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-328X(99)00034-0"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)31878-6"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21228580"},{"issue":"3","key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"iii18","DOI":"10.1136\/ard.60.90003.iii18","article-title":"Novel targets for interleukin 18 binding protein","volume":"60","author":"Dinarello C. 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