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Previous studies of our group revealed some behavioral impairments and a mutation in the lysine (K)\u2010specific methyltransferase 2D (Kmt2d) gene. Because mutations in the KMT2D gene in humans are mainly responsible for Kabuki syndrome, this study was proposed to validate\n                    <jats:italic>bapa<\/jats:italic>\n                    mice as a model of Kabuki syndrome. Besides other symptoms, Kabuki syndrome is characterized by increased susceptibility to infections and speech impairments, usually diagnosed in the early childhood. Thus, juvenile male and female\n                    <jats:italic>bapa<\/jats:italic>\n                    mice were studied in different developmental stages (prepubertal period and puberty). To induce sickness behavior and to study infection susceptibility responses, lipopolysaccharide (LPS) was used. To study oral communication, ultrasonic vocalizations were evaluated. Behavioral (open\u2010field test) and central (astrocytic glial fibrillary acidic protein [GFAP] and tyrosine hydroxylase [TH]) evaluations were also performed. Control and\n                    <jats:italic>bapa<\/jats:italic>\n                    female mice emitted 31\u2010kHz ultrasounds on prepubertal period when exploring a novel environment, a frequency not yet described for mice, being defined as 31\u2010kHz exploratory vocalizations. Males, LPS, and puberty inhibited these vocalizations.\n                    <jats:italic>Bapa<\/jats:italic>\n                    mice presented increased motor\/exploratory behaviors on prepubertal period due to increased striatal TH expression, revealing striatal dopaminergic system hyperactivity. Combining open\u2010field behavior and GFAP expression,\n                    <jats:italic>bapa<\/jats:italic>\n                    mice did not develop LPS tolerance, that is, they remained expressing signs of sickness behavior after LPS challenge, being more susceptible to infectious\/inflammatory processes. It was concluded that\n                    <jats:italic>bapa<\/jats:italic>\n                    mice is a robust experimental model of Kabuki syndrome.\n                  <\/jats:p>","DOI":"10.1002\/jnr.25050","type":"journal-article","created":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T04:26:24Z","timestamp":1648787184000},"page":"1438-1451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<i>Bate palmas<\/i>\n                    mutant mice as a model of Kabuki syndrome: Higher susceptibility to infections and vocalization impairments?"],"prefix":"10.1002","volume":"100","author":[{"given":"Thiago B.","family":"Kirsten","sequence":"first","affiliation":[{"name":"Psychoneuroimmunology Laboratory, Program in Environmental and Experimental Pathology Paulista University  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ericka P.","family":"Silva","sequence":"additional","affiliation":[{"name":"Psychoneuroimmunology Laboratory, Program in Environmental and Experimental Pathology Paulista University  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thalles F.","family":"Biondi","sequence":"additional","affiliation":[{"name":"Psychoneuroimmunology Laboratory, Program in Environmental and Experimental Pathology Paulista University  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula S.","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Psychoneuroimmunology Laboratory, Program in Environmental and Experimental Pathology Paulista University  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina V.","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Psychoneuroimmunology Laboratory, Program in Environmental and Experimental Pathology Paulista University  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia M. 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C.","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Veterinary Medicine and Animal Science University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo F.","family":"Bondan","sequence":"additional","affiliation":[{"name":"Psychoneuroimmunology Laboratory, Program in Environmental and Experimental Pathology Paulista University  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria M.","family":"Bernardi","sequence":"additional","affiliation":[{"name":"Psychoneuroimmunology Laboratory, Program in Environmental and Experimental Pathology Paulista University  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1025015928129"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2011.03.060"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3009278"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes12040468"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yhbeh.2007.07.006"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.112233"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2006.09.006"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1228261"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30722"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2013.10.004"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3004-14.2015"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2016.11.006"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(99)70207-6"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3356-12.2013"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2020.01.019"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0134565"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.23089"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0120263"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2010.03.009"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(81)80256-9"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2020.104835"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-183X.2010.00603.x"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1006\/brbi.2001.0643"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2011.11.021"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18102219"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5683"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2006000900009"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.10020"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11259-019-09766-8"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.30332"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36072"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1080\/1028415X.2018.1512783"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0169446"},{"key":"e_1_2_10_35_1","volume-title":"National Research Council. 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