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C57Bl\/6 male mice were injected with [\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG and randomly separated into three groups. Groups 1 and 2 were kept conscious after [\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG administration and after 5\u2009min received saline or cocaine (20\u2009mg\/kg). The animals in group 1 (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u20095) were then evaluated in the open field for 30\u2009min and those from group 2 (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u20096) were kept alone in a home cage for the same period. Forty\u2010five minutes after [\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG administration, images were acquired for 30\u2009min. Group 3 (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u20096) was kept anesthetized and image acquisition started immediately after tracer injection, for 75\u00a0min. Saline (Day 1) or cocaine (Day 2) was injected 5\u2009min after starting acquisition. Another set of animals (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u20095) were treated with cocaine every other day for 10\u2009days or saline (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u20096) and were scanned with the dynamic protocol to verify its efficacy. [\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG uptake increased after cocaine administration when compared to baseline only in animals kept under anesthesia. No brain effect of cocaine was observed in animals submitted to the open field or kept in the home cage. The use of anesthesia is essential to visualize cocaine\u2010induced changes in brain metabolism by [\n                    <jats:sup>18<\/jats:sup>\n                    F]FDG PET, providing an interesting preclinical approach to investigate na\u00efve subjects and enabling a bidirectional translational science approach for better understanding of cocaine use disorder.\n                  <\/jats:p>","DOI":"10.1002\/jnr.25102","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T12:32:24Z","timestamp":1656765144000},"page":"1876-1889","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["[\n                    <scp>\n                      <sup>18<\/sup>\n                      F\n                    <\/scp>\n                    ]\n                    <scp>FDG<\/scp>\n                    brain uptake of\n                    <scp>C57Bl<\/scp>\n                    \/6 male mice is affected by locomotor activity after cocaine use: A small animal positron emission tomography study"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6526-2915","authenticated-orcid":false,"given":"Lidia Emmanuela Wiazowski","family":"Spelta","sequence":"first","affiliation":[{"name":"Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6096-3341","authenticated-orcid":false,"given":"Caroline Cristiano","family":"Real","sequence":"additional","affiliation":[{"name":"Laboratory of Nuclear Medicine, Department of Radiology and Oncology, Faculty of Medicine University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0956-2790","authenticated-orcid":false,"given":"Carlos Alberto","family":"Buchpiguel","sequence":"additional","affiliation":[{"name":"Laboratory of Nuclear Medicine, Department of Radiology and Oncology, Faculty of Medicine University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1766-2786","authenticated-orcid":false,"given":"Daniele","family":"de Paula Faria","sequence":"additional","affiliation":[{"name":"Laboratory of Nuclear Medicine, Department of Radiology and Oncology, Faculty of Medicine University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0076-5017","authenticated-orcid":false,"given":"Tania","family":"Marcourakis","sequence":"additional","affiliation":[{"name":"Department of Clinical and Toxicological Analysis, School of Pharmaceutical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2007.07.012"},{"key":"e_1_2_11_3_1","first-page":"1127","article-title":"Skeletal muscle uptake of Fluorine\u201018\u2010FDG: Effect of Oral diazepam","volume":"37","author":"Barrington S. 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