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Since spinal nociceptive afferents contribute to both the sensation of painful stimuli as well as reflex circuits involved in movement, we investigated the relationship between prenatal hypoxia\u2013ischemia (HI) injury which can cause CP, and possible changes in spinal nociceptive circuitry. To do this, we examined nociceptive afferents and mechanical and thermal sensitivity of New Zealand White rabbit kits after prenatal HI or a sham surgical procedure. As described previously, a range of motor deficits similar to spastic CP was observed in kits born naturally after HI (40\u00a0min at ~70%\u201380% gestation). We found that HI caused an expansion of peptidergic afferents (marked by expression of calcitonin gene\u2010related peptide) in both the superficial and deep dorsal horn at postnatal day (P)5. Non\u2010peptidergic nociceptive afferent arborization (labeled by isolectin B4) was unaltered in HI kits, but overlap of the two populations (peptidergic and non\u2010peptidergic nociceptors) was increased by HI. Density of glial fibrillary acidic protein was unchanged within spinal cord white matter regions important in nociceptive transmission at P5. We found that mechanical and thermal nociception was enhanced in HI kits even in the absence of motor deficits. These findings suggest that prenatal HI injury impacts spinal sensory pathways in addition to the more well\u2010established disruptions to descending motor circuits. In conclusion, changes to spinal nociceptive circuitry could disrupt spinal reflexes and contribute to pain experienced by individuals with CP.<\/jats:p>","DOI":"10.1002\/jnr.25108","type":"journal-article","created":{"date-parts":[[2022,7,15]],"date-time":"2022-07-15T15:05:34Z","timestamp":1657897534000},"page":"1951-1966","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Enhanced nociceptive behavior and expansion of associated primary afferents in a rabbit model of cerebral palsy"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7861-7778","authenticated-orcid":false,"given":"Emily J.","family":"Reedich","sequence":"first","affiliation":[{"name":"George and Anne Ryan Institute for Neuroscience University of Rhode Island  Kingston Rhode Island USA"},{"name":"Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy University of Rhode Island  Kingston Rhode 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