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Considering this, it becomes extremely relevant to pursue alternative therapeutic approaches, in order to provide appropriate treatment for those patients and also improve their quality of life. In the light of that, this review aims to discuss some innovative options for the treatment of epilepsy, which are currently under investigation, addressing strategies that go from therapeutic compounds to clinical procedures. For instance, peptides derived from animal venoms, such as wasps, spiders, and scorpions, demonstrate to be promising antiepileptic molecules, acting on a variety of targets. Other options are cannabinoids and compounds that modulate the endocannabinoid system, since it is now known that this network is involved in the pathophysiology of epilepsy. Furthermore, neurostimulation is another strategy, being an alternative clinical procedure for drug\u2010resistant patients who are not eligible for palliative surgeries.<\/jats:p>","DOI":"10.1002\/jnr.25114","type":"journal-article","created":{"date-parts":[[2022,8,8]],"date-time":"2022-08-08T02:45:56Z","timestamp":1659926756000},"page":"1969-1986","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Innovative treatments for epilepsy: Venom peptides, cannabinoids, and neurostimulation"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7050-5560","authenticated-orcid":false,"given":"Larissa Silva de","family":"Lima","sequence":"first","affiliation":[{"name":"Laboratory of Neuropharmacology, Department of Physiological Sciences, Institute of Biological Sciences University of Brasilia  Brasilia 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