{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T00:14:29Z","timestamp":1788480869390,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","award":["K01NS104172"],"award-info":[{"award-number":["K01NS104172"]}],"id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["pericles.pericles-gcp.literatumonline.com"],"crossmark-restriction":true},"short-container-title":["J of Neuroscience Research"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Sleep problems are prevalent in autism spectrum disorder (ASD), can be observed before diagnosis, and are associated with increased restricted and repetitive behaviors. Therefore, sleep abnormalities may be a core feature of the disorder, but the developmental trajectory remains unknown. Animal models provide a unique opportunity to understand sleep ontogenesis in ASD. Previously we showed that adult mice with a truncation in the high\u2010confidence ASD gene\n                    <jats:italic>Shank3<\/jats:italic>\n                    (Shank3\n                    <jats:sup>\u2206C<\/jats:sup>\n                    ) recapitulate the clinical sleep phenotype. In this study we used longitudinal electro\u2010encephalographic (EEG) recordings to define, for the first time, changes in sleep from weaning to young adulthood in an ASD mouse model. We show that Shank3\n                    <jats:sup>\u2206C<\/jats:sup>\n                    male mice sleep less overall throughout their lifespan, have increased rapid eye movement (REM) sleep early in life despite significantly reduced non\u2010rapid eye movement (NREM) sleep, and have abnormal responses to increased sleep pressure that emerge during a specific developmental period. We demonstrate that the ability to fall asleep quickly in response to sleep loss develops normally between 24 and 30\u2009days in mice. However, mutants are unable to reduce sleep latency after periods of prolonged waking and maintain the same response to sleep loss regardless of age. This phenomenon seems independent of homeostatic NREM sleep slow\u2010wave dynamics. Overall, our study recapitulates both preclinical models and clinical studies showing that reduced sleep is consistently associated with ASD and suggests that problems falling asleep may reflect abnormal development of sleep and arousal mechanisms.\n                  <\/jats:p>","DOI":"10.1002\/jnr.25119","type":"journal-article","created":{"date-parts":[[2022,9,3]],"date-time":"2022-09-03T02:38:46Z","timestamp":1662172726000},"page":"2174-2186","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Shank3 influences mammalian sleep development"],"prefix":"10.1002","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7942-7685","authenticated-orcid":false,"given":"Elizabeth","family":"Medina","sequence":"first","affiliation":[{"name":"Department of Translational Medicine and Physiology, Sleep and Performance Research Center, Elson S. Floyd College of Medicine Washington State University  Spokane Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah","family":"Schoch","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine and Physiology, Sleep and Performance Research Center, Elson S. Floyd College of Medicine Washington State University  Spokane Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlyn","family":"Ford","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine and Physiology, Sleep and Performance Research Center, Elson S. Floyd College of Medicine Washington State University  Spokane Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2377-9999","authenticated-orcid":false,"given":"Taylor","family":"Wintler","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine and Physiology, Sleep and Performance Research Center, Elson S. Floyd College of Medicine Washington State University  Spokane Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristan G.","family":"Singletary","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine and Physiology, Sleep and Performance Research Center, Elson S. Floyd College of Medicine Washington State University  Spokane Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8444-9600","authenticated-orcid":false,"given":"Lucia","family":"Peixoto","sequence":"additional","affiliation":[{"name":"Department of Translational Medicine and Physiology, Sleep and Performance Research Center, Elson S. Floyd College of Medicine Washington State University  Spokane Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593\u2010022\u201001076\u20108"},{"issue":"3","key":"e_1_2_12_3_1","first-page":"195","article-title":"A two process model of sleep regulation","volume":"1","author":"Borb\u00e9ly A. A.","year":"1982","journal-title":"Human Neurobiology"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13229\u2010015\u20100020\u20105"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2022.101595"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40675\u2010020\u201000190\u2010y"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1997.272.6.R1792"},{"issue":"1","key":"e_1_2_12_8_1","first-page":"R148","article-title":"Effects of sleep deprivation in neonatal rats","volume":"275","author":"Frank M. G.","year":"1998","journal-title":"The American Journal of Physiology"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/sleep\/zsw077"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.21-08-02610.2001"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15014"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ridd.2014.03.037"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sleep.2020.08.035"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jsr.12055"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.42819"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aav5188"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3017\u201013.2013"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10803\u2010020\u201004438\u2010y"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.2019.19060666"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s\u20100037\u20101604353"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci3010318"},{"issue":"1","key":"e_1_2_12_22_1","first-page":"1","article-title":"Sleep characteristics in healthy children from birth to 6\u2009years of age in the urban area of Rome","volume":"19","author":"Ottaviano S.","year":"1996","journal-title":"Sleep"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm10173893"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0207031"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.152.3722.604"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00385"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11920\u2010017\u20100782\u2010x"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1700983114"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24619"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.5746\u201012.2013"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijdevneu.2004.05.001"}],"container-title":["Journal of Neuroscience Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.25119","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/jnr.25119","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/jnr.25119","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,29]],"date-time":"2023-11-29T06:26:31Z","timestamp":1701239191000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/jnr.25119"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,2]]},"references-count":30,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1002\/jnr.25119"],"URL":"https:\/\/doi.org\/10.1002\/jnr.25119","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.1002\/JNR.25119\/v2\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25119\/v1\/review3","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25119\/v2\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25119\/v3\/decision1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25119\/v1\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25119\/v2\/review2","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25119\/v1\/review1","asserted-by":"object"},{"id-type":"doi","id":"10.1002\/JNR.25119\/v1\/decision1","asserted-by":"object"}],"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.03.10.434728","asserted-by":"object"}]},"ISSN":["0360-4012","1097-4547"],"issn-type":[{"value":"0360-4012","type":"print"},{"value":"1097-4547","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,2]]},"assertion":[{"value":"2021-11-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}